Human PDAP1 Recombinant Protein (RPPB4205)
- SKU:
- RPPB4205
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13442
Description
| Product Name: | Human PDAP1 Recombinant Protein |
| Product Code: | RPPB4205 |
| Size: | 20µg |
| Species: | Human |
| Target: | PDAP1 |
| Synonyms: | PAP1, HASPP28. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The PDAP1 solution (1mg/ml) contains 20mM Tris-HCl pH-8, 2mM DTT, 0.1M NaCl, 0.1mM PMSF & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MPKGGRKGGH KGRARQYTSP EEIDAQLQAE KQKAREEEEQ KEGGDGAAGD PKKEKKSLDS DESEDEEDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD LDGPKELSRR EREEIEKQKA KERYMKMHLA GKTEQAKADL ARLAIIRKQR EEAARKKEEE RKAKDDATLS GKRMQSLSLN KLEHHHHHH |
PDAP1, increases PDGFA-stimulated cell growth in fibroblasts, however inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 show significantly less apoptosis on exposure to TNF-alpha.
PDAP1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids (1-181 a.a.) and having a molecular mass of 21.7 kDa. The PDAP1 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PDAP1: Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. Belongs to the PDAP1 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q22.1 Biological Process: cell proliferation; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q13442 |
| NCBI GenInfo Identifier: | 2498464 |
| NCBI Gene ID: | 11333 |
| NCBI Accession: | Q13442.1 |
| UniProt Secondary Accession: | Q13442,Q92906, D6W5S5, |
| UniProt Related Accession: | Q13442 |
| Molecular Weight: | 20,630 Da |
| NCBI Full Name: | 28 kDa heat- and acid-stable phosphoprotein |
| NCBI Synonym Full Names: | PDGFA associated protein 1 |
| NCBI Official Symbol: | PDAP1�� |
| NCBI Official Synonym Symbols: | PAP; PAP1; HASPP28�� |
| NCBI Protein Information: | 28 kDa heat- and acid-stable phosphoprotein |
| UniProt Protein Name: | 28 kDa heat- and acid-stable phosphoprotein |
| UniProt Synonym Protein Names: | PDGF-associated protein; PAP; PDGFA-associated protein 1; PAP1 |
| Protein Family: | 28 kDa heat- and acid-stable phosphoprotein |
| UniProt Gene Name: | PDAP1�� |
| UniProt Entry Name: | HAP28_HUMAN |
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