Immune Checkpoint Recombinant Proteins
Human PD-L1 Recombinant Protein (mFc-His Tag) (HDPT0023)
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- SKU:
- HDPT0023
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immune Checkpoint
Description
Human PD-L1 Recombinant Protein (mFc-His Tag)
| Description: | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. |
| Product name: | Human PD-L1 Recombinant Protein (mFc-His Tag) |
| Synonyms: | PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1 |
| Type: | protein |
| Size: | 50 µg |
| Name: | PD-L1 |
| Origin: | Human |
| Source: | HEK293 |
| Protein Type: | Recombinant |
| Application: | ELISA |
| Purity: | > 95% |
| Purification: | affinity purification |
| Format: | Lyophilized |
| Conjugate: | C-Mouse Fc and 6×His tag |
| Storage: | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage: | Research use only |
| Buffer: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Reconstitution: | Reconstitute with deionized water |
| Sequence: | PD-L1（Phe19-Arg328）+mFc（Pro99-Lys330）+6×His tag |
| Gene ID: | 29126 |
| Uniprot: | Q9NZQ7 |
| Molecular Weight: | 52.3 kDa |
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