Immunology Recombinant Proteins
Human PD-L1/B7-H1/CD274 Recombinant Protein (RPES5173)
- SKU:
- RPES5173
Description
Human PD-L1/B7-H1/CD274 Recombinant Protein
CD274; also known as B7-H1 or programmed death ligand 1 (PD-L1); is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1; CD274; B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells; PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly; it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
| Product Name: | Human PD-L1/B7-H1/CD274 Recombinant Protein (RPES5173) |
| Product Code: | RPES5173 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 |
| Accession: | Q9NZQ7 |
| Sequence: | Phe19-Thr239 |
| Fusion tag: | C-Fc-Avi |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Biotinylated Recombinant Human PD-L1 is produced by our Mammalianexpression system and the target gene encoding Phe19-Thr239 is expressed with a Fc; Avi tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 54.2 kDa |
| AP Mol Mass: | 70-95 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Immunology |
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