Enzymes Recombinant Proteins

Human PCOLCE Recombinant Protein (RPPB5824)

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SKU:
RPPB5824
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15113
Research Area:
Enzymes

Description

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Product Name:Human PCOLCE Recombinant Protein
Product Code:RPPB5824
Size:25µg
Species:Human
Target:PCOLCE
Synonyms:ProcollagenC-Endopeptidase Enhancer, Procollagen C-Proteinase Enhancer 1, Type IProcollagen COOH-Terminal Proteinase Enhancer, Type 1 Procollagen C-ProteinaseEnhancer Protein, Procollagen COOH-Terminal Proteinase Enhancer 1, PCPE-1, PCPE1,Procollagen, Type 1, COOH-Terminal Proteinase Enhancer, ProcollagenC-Endopeptidase Enhancer 1, COOH-Terminal Proteinase Enhancer, Procollagen,Type 1, PCPE, Procollagen C-endopeptidase enhancer 1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:PCOLCE protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSQTPNYTRPVFLCGGDVK GESGYVASEG FPNLYPPNKE CIWTITVPEG QTVSLSFRVF DLELHPACRY DALEVFAGSGTSGQRLGRFC GTFRPAPLVA PGNQVTLRMT TDEGTGGRGF LLWYSGRATS GTEHQFCGGR LEKAQGTLTTPNWPESDYPP GISCSWHIIA PPDQVIALTF EKFDLEPDTY CRYDSVSVFN GAVSDDSRRL GKFCGDAVPGSISSEGNELL VQFVSDLSVT ADGFSASYKT LPRGTAKEGQ GPGPKRGTEP KVKLPPKSQP PEKTEESPSAPDAPTCPKQC RRTGTLQSNF CASSLVVTAT VKSMVREPGE GLAVTVSLIG AYKTGGLDLP SPPTGASLKFYVPCKQCPPM KKGVSYLLMG QVEENRGPVL PPESFVVLHR PNQDQILTNL SKRKCPSQPV RAAASQD

Procollagen C-endopeptidase enhancer 1, also known as PCOLCE binds tothe C-terminal propeptide of type I procollagen and enhances procollagenC-proteinase activity. In addition, C-terminal processed part of PCPE (CT-PCPE)has a metalloproteinase inhibitory activity. Among the diseases which are associatedwith PCOLCE: bone fracture & oculopharyngeal muscular dystrophy.

PCOLCE Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 447 amino acids (26-449 a.a) and having amolecular mass of 47.9kDa.PCOLCE is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
NCBI Summary:Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
UniProt Code:Q15113
NCBI GenInfo Identifier:6919941
NCBI Gene ID:5118
NCBI Accession:Q15113.2
UniProt Secondary Accession:Q15113,O14550, B2R9E1,
UniProt Related Accession:Q15113
Molecular Weight:47,972 Da
NCBI Full Name:Procollagen C-endopeptidase enhancer 1
NCBI Synonym Full Names:procollagen C-endopeptidase enhancer
NCBI Official Symbol:PCOLCE��
NCBI Official Synonym Symbols:PCPE; PCPE1; PCPE-1��
NCBI Protein Information:procollagen C-endopeptidase enhancer 1
UniProt Protein Name:Procollagen C-endopeptidase enhancer 1
UniProt Synonym Protein Names:Procollagen COOH-terminal proteinase enhancer 1; PCPE-1; Procollagen C-proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer
Protein Family:Procollagen C-endopeptidase enhancer
UniProt Gene Name:PCOLCE��
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