Enzymes Recombinant Proteins
Human PCOLCE Recombinant Protein (RPPB2076)
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- SKU:
- RPPB2076
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15113
- Research Area:
- Enzymes
Description
| Product Name: | Human PCOLCE Recombinant Protein |
| Product Code: | RPPB2076 |
| Size: | 10µg |
| Species: | Human |
| Target: | PCOLCE |
| Synonyms: | Procollagen C-endopeptidase enhancer 1,� Procollagen COOH-terminal proteinase enhancer 1,� PCPE-1,� Procollagen C-proteinase enhancer 1,� Type 1 procollagen C-proteinase enhancer protein,� Type I procollagen COOH-terminal proteinase enhancer,� PCOLCE,� PCPE1,� Procollagen C-Endopeptidase Enhancer, Procollagen C-Proteinase, Enhancer 1, Procollagen, Type 1, COOH-Terminal Proteinase Enhancer, Type I Procollagen COOH-Terminal Proteinase Enhancer, Type 1 Procollagen C-Proteinase Enhancer Protein, Procollagen COOH-Terminal Proteinase Enhancer 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | PCOLCE protein solution (0.25mg/ml) contains 20mM Tris-HCl (pH 8.0), 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPQTPNYTR PVFLCGGDVK GESGYVASEG FPNLYPPNKE CIWTITVPEG QTVSLSFRVF DLELHPACRY DALEVFAGSG TSGQRLGRFC GTFRPAPLVA PGNQVTLRMT TDEGTGGRGF LLWYSGRATS GTEHQFCGGR LEKAQGTLTT PNWPESDYPP GISCSWHIIA PPDQVIALTF EKFDLEPDTY CRYDSVSVFN GAVSDDSRRL GKFCGDAVPG SISSEGNELL VQFVSDLSVT ADGFSASYKT LPRGTAKEGQ GPGPKRGTEP KVKLPPKSQP PEKTEESPSA PDAPTCPKQC RRTGTLQSNF CASSLVVTAT VKSMVREPGE GLAVTVSLIG AYKTGGLDLP SPPTGASLKF YVPCKQCPPM KKGVSYLLMG QVEENRGPVL PPESFVVLHR PNQDQILTNL SKRKCPSQPV RAAASQDHHH HHH |
Procollagen C-endopeptidase enhancer 1, also known as PCOLCE binds tothe C-terminal propeptide of type I procollagen and enhances procollagenC-proteinase activity. In addition, C-terminal processed part of PCPE (CT-PCPE)has a metalloproteinase inhibitory activity. Among the diseases which are associatedwith PCOLCE: bone fracture & oculopharyngeal muscular dystrophy.
PCOLCE produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 433 amino acids (26-449 a.a.) and having a molecular mass of 46.6kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).PCOLCE is expressed with an 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. |
| NCBI Summary: | Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15113 |
| NCBI GenInfo Identifier: | 6919941 |
| NCBI Gene ID: | 5118 |
| NCBI Accession: | Q15113.2 |
| UniProt Secondary Accession: | Q15113,O14550, B2R9E1, |
| UniProt Related Accession: | Q15113 |
| Molecular Weight: | 47,972 Da |
| NCBI Full Name: | Procollagen C-endopeptidase enhancer 1 |
| NCBI Synonym Full Names: | procollagen C-endopeptidase enhancer |
| NCBI Official Symbol: | PCOLCE�� |
| NCBI Official Synonym Symbols: | PCPE; PCPE1; PCPE-1�� |
| NCBI Protein Information: | procollagen C-endopeptidase enhancer 1 |
| UniProt Protein Name: | Procollagen C-endopeptidase enhancer 1 |
| UniProt Synonym Protein Names: | Procollagen COOH-terminal proteinase enhancer 1; PCPE-1; Procollagen C-proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer |
| Protein Family: | Procollagen C-endopeptidase enhancer |
| UniProt Gene Name: | PCOLCE�� |
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