Human PCNP Recombinant Protein (RPPB4201)

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RPPB4201

Description

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Product Name:Human PCNP Recombinant Protein
Product Code:RPPB4201
Size:20µg
Species:Human
Target:PCNP
Synonyms:PEST proteolytic signal-containing nuclear protein, PCNP, PEST-containing nuclear protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:PCNP protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMADGKA GDEKPEKSQR AGAAGGPEEE AEKPVKTKTV SSSNGGESSS RSAEKRSAEE EAADLPTKPT KISKFGFAIG SQTTKKASAI SIKLGSSKPK ETVPTLAPKT LSVAAAFNED EDSEPEEMPP EAKMRMKNIG RDTPTSAGPN SFNKGKHGFS DNQKLWERNI KSHLGNVHDQ DN

PEST proteolytic signal containing nuclear protein (PCNP) is a nuclear protein involved in cell cycle regulation and tumorigenesis. The PCNP protein is ubiquitinated post-translationally by NIRF (an ubiquitin ligase). The PCNP exists as 3 isoforms produced by alternative splicing events.

PCNP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 202 amino acids (1-178 a.a.) and having a molecular mass of 21.5kDa.PCNP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PCNP: a nuclear protein that may be involved in cell cycle regulation. Ubiquitination by UHRF2 leads to its subsequent proteasomal degradation. Three alternatively spliced isoforms have been reported.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3q12.3

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; cell cycle

UniProt Code:Q8WW12
NCBI GenInfo Identifier:9966826
NCBI Gene ID:57092
NCBI Accession:NP_065090.1
UniProt Secondary Accession:Q8WW12,Q53GF3, Q6AI44, Q96CU3, Q9NS81, B2RBE7, D3DN52
UniProt Related Accession:Q8WW12
Molecular Weight:6,233 Da
NCBI Full Name:Homo sapiens PEST proteolytic signal containing nuclear protein (PCNP), mRNA
NCBI Synonym Full Names:PEST proteolytic signal containing nuclear protein
NCBI Official Symbol:PCNP��
NCBI Protein Information:PEST proteolytic signal-containing nuclear protein; PEST-containing nuclear protein
UniProt Protein Name:PEST proteolytic signal-containing nuclear protein
Protein Family:PEST proteolytic signal-containing nuclear protein
UniProt Gene Name:PCNP��
UniProt Entry Name:PCNP_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WW12
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