Human PARVA Recombinant Protein (RPPB4189)
- SKU:
- RPPB4189
Description
| Product Name: | Human PARVA Recombinant Protein |
| Product Code: | RPPB4189 |
| Size: | 20µg |
| Species: | Human |
| Target: | PARVA |
| Synonyms: | Alpha-parvin, Actopaxin, CH-ILKBP, Calponin-like integrin-linked kinase-binding protein, Matrix-remodeling-associated protein 2, PARVA, MXRA2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PARVA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMATSPQK SPSVPKSPTP KSPPSRKKDD SFLGKLGGTL ARRKKAKEVS ELQEEGMNAI NLPLSPIPFE LDPEDTMLEE NEVRTMVDPN SRSDPKLQEL MKVLIDWIND VLVGERIIVK DLAEDLYDGQ VLQKLFEKLE SEKLNVAEVT QSEIAQKQKL QTVLEKINET LKLPPRSIKW NVDSVHAKSL VAILHLLVAL SQYFRAPIRL PDHVSIQVVV VQKREGILQS RQIQEEITGN TEALSGRHER DAFDTLFDHA PDKLNVVKKT LITFVNKHLN KLNLEVTELE TQFADGVYLV LLMGLLEGYF VPLHSFFLTP DSFEQKVLNV SFAFELMQDG GLEKPKPRPE DIVNCDLKST LRVLYNLFTK YRNVE |
Alpha-parvin (PARVA) belongs to the parvin family of actin-binding proteins. PARVA has a role in the regulation of cell adhesion, cytoskeleton organization, motility and survival as well as in ciliogenesis. Parvins are related with focal contacts and contain calponin homology domains which connect to actin filaments. PARVA is extensively expressed, with the highest levels in heart, skeletal muscle, kidney and liver.
PARVA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 395 amino acids (1-372 a.a) and having a molecular mass of 44.6kDa.PARVA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PARVA: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Adaptor/scaffoldChromosomal Location of Human Ortholog: 11p15.3Cellular Component: focal adhesion; lamellipodium; cytoplasm; plasma membrane; nucleus; Z disc; cytosol; actin cytoskeletonMolecular Function: protein binding; actin bindingBiological Process: heterotypic cell-cell adhesion; regulation of cell shape; actin cytoskeleton reorganization; establishment and/or maintenance of cell polarity; sprouting angiogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9NVD7 |
| NCBI GenInfo Identifier: | 20139236 |
| NCBI Gene ID: | 55742 |
| NCBI Accession: | Q9NVD7.1 |
| UniProt Secondary Accession: | Q9NVD7,Q96C85, Q9HA48 |
| UniProt Related Accession: | Q9NVD7 |
| Molecular Weight: | 372 |
| NCBI Full Name: | Alpha-parvin |
| NCBI Synonym Full Names: | parvin, alpha |
| NCBI Official Symbol: | PARVA�� |
| NCBI Official Synonym Symbols: | MXRA2; CH-ILKBP�� |
| NCBI Protein Information: | alpha-parvin; actopaxin; matrix-remodeling-associated protein 2; calponin-like integrin-linked kinase-binding protein |
| UniProt Protein Name: | Alpha-parvin |
| UniProt Synonym Protein Names: | Actopaxin; CH-ILKBP; Calponin-like integrin-linked kinase-binding protein; Matrix-remodeling-associated protein 2 |
| Protein Family: | Parvalbumin |
| UniProt Gene Name: | PARVA�� |
| UniProt Entry Name: | PARVA_HUMAN |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Uniprot: |
Q9NVD7 |
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