Human PAEP Recombinant Protein (RPPB4182)
- SKU:
- RPPB4182
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09466
Description
| Product Name: | Human PAEP Recombinant Protein |
| Product Code: | RPPB4182 |
| Size: | 10µg |
| Species: | Human |
| Target: | PAEP |
| Synonyms: | GD, GdA, GdF, GdS, PAEG, PEP, PP14, Glycodelin, Placental protein 14, Pregnancy-associated endometrial alpha-2 globulin, PEG, Progestagen-associated endometrial protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PAEP protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDIPQTK QDLELPKLAG TWHSMAMATN NISLMATLKA PLRVHITSLL PTPEDNLEIV LHRWENNSCV EKKVLGEKTE NPKKFKINYT VANEATLLDT DYDNFLFLCL QDTTTPIQSM MCQYLARVLV EDDEIMQGFI RAFRPLPRHL WYLLDLKQME EPCRF |
Progesterone-Associated Endometrial Protein (PAEP) is a member of the kernel lipocalin super family whose members share rather low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. PAEP protein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin.
PAEP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 185 amino acids (19-180a.a) and having a molecular mass of 21kDa. PAEP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PAEP: This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy. Belongs to the calycin superfamily. Lipocalin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q34.3 Molecular Function:protein binding Biological Process: apoptosis; multicellular organismal development; positive regulation of granulocyte macrophage colony-stimulating factor production |
| NCBI Summary: | This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P09466 |
| NCBI GenInfo Identifier: | 130701 |
| NCBI Gene ID: | 5047 |
| NCBI Accession: | P09466.2 |
| UniProt Secondary Accession: | P09466,Q5T6T1, Q9UG92, |
| UniProt Related Accession: | P09466 |
| Molecular Weight: | 21kDa |
| NCBI Full Name: | Glycodelin |
| NCBI Synonym Full Names: | progestagen associated endometrial protein |
| NCBI Official Symbol: | PAEP�� |
| NCBI Official Synonym Symbols: | GD; GdA; GdF; GdS; PEP; PAEG; PP14�� |
| NCBI Protein Information: | glycodelin |
| UniProt Protein Name: | Glycodelin |
| UniProt Synonym Protein Names: | Placental protein 14; PP14; Pregnancy-associated endometrial alpha-2 globulin; PAEG; PEG; Progestagen-associated endometrial protein; Progesterone-associated endometrial protein |
| Protein Family: | Glycodelin |
| UniProt Gene Name: | PAEP�� |
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