Human P21 Recombinant Protein (His tag)

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SKU:
RPES5505
Product Type:
Recombinant Protein
Species:
Human

Description

Product Name:Human P21 Recombinant Protein (His tag)
Product Code:RPES5505
Size:20µg
Species:Human
Expression Host:E.coli
Synonyms:CAP20, CDK-interacting protein 1, CDKI, CDKN1, CDN1A, CIP1, CDKN1A, Cyclin Dependent Kinase Inhibitor 1A, DNA Synthesis Inhibitor, MDA-6, MDA6, Melanoma differentiation-associated protein 6, P21cip1, P21waf, PIC1, SDI1, SLC12A9, WAF1
Mol Mass:13.64 kDa
AP Mol Mass:18 kDa
Tag:N-His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Gly 40-Pro 164
Accession:P38936
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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