Human OX40/TNFRSF4 Recombinant Protein (RPES3831)
- SKU:
- RPES3831
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human OX40/TNFRSF4 Recombinant Protein
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
| Product Name: | Human OX40/TNFRSF4 Recombinant Protein (RPES3831) |
| Product Code: | RPES3831 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Tumor necrosis factor receptor superfamily member 4,TNFRSF4,OX40,CD134,Txgp1,ACT35,IMD16,TXGP1L |
| Accession: | NP_003318.1 |
| Sequence: | Leu29-Ala216 |
| Fusion tag: | C-6His |
| Activity: | Immobilized Human OX40L-His(Cat: PKSH032842) at 0.1µg/ml(100 ?l/well) can bind Biotinylated Human OX40-His. The ED50 of Human OX40-His is 14.89 ug/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human OX40L Receptor is produced by our Mammalian expression system and the target gene encoding Leu29-Ala216 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 21.0 kDa |
| AP Mol Mass: | 35-40 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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