Enzymes Recombinant Proteins
Human Ornithine Aminotransferase Recombinant Protein (RPPB2059)
- SKU:
- RPPB2059
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P04181
- Research Area:
- Enzymes
Description
| Product Name: | Human Ornithine Aminotransferase Recombinant Protein |
| Product Code: | RPPB2059 |
| Size: | 25µg |
| Species: | Human |
| Target: | Ornithine Aminotransferase |
| Synonyms: | DKFZp781A11155, HOGA, OATASE, Ornithine aminotransferase mitochondrial, Ornithine--oxo-acid aminotransferase, OAT, OKT, GACR. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The Ornithine Aminotransferase protein solution contains 20mM Tris, pH-8, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MTVQGPPTSD DIFEREYKYG AHNYHPLPVA LERGKGIYLW DVEGRKYFDF LSSYSAVNQG HCHPKIVNAL KSQVDKLTLT SRAFYNNVLG EYEEYITKLF NYHKVLPMNT GVEAGETACK LARKWGYTVK GIQKYKAKIV AAGNFWGRT LSAISSSTDP TSYDGFGPFM PGFDIIPYND LPALERALQD PNVAAFMVEP IQGEAGVVVP DPGYLMGVRE LCTRHQVLFI ADEIQTGLAR TGRWLAVDYE NVRPDIVLLG KALSGGLYPV SAVLCDDDIM LTIKPGEHGS TYGGNPLGCR VAIAALEVLE EENLAENADK LGIILRNELM KLPSDVVTAV RGKGLLNAIV IKETKDWDAW KVCLRLRDNG LLAKPTHGDI IRFAPPLVIK EDELRESIEI INKTILSF |
Ornithine Aminotransferase is a mitochondrial enzyme which is an important factor that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Ornithine Aminotransferase mutations result in a deficiency that cause the autosomal recessive eye disease Gyrate Atrophy.
Ornithine Aminotransferase Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 408 amino acids (33-439 a.a.) and having a molecular wieght of 45.2kDa.The Ornithine Aminotransferase is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; EC 2.6.1.13; Transferase; Mitochondrial Chromosomal Location of Human Ortholog: 10q26 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:identical protein binding; ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding Biological Process: amino acid biosynthetic process; arginine catabolic process to glutamate; arginine catabolic process to proline via ornithine; visual perception Disease: Gyrate Atrophy Of Choroid And Retina |
| NCBI Summary: | This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P04181 |
| NCBI GenInfo Identifier: | 129018 |
| NCBI Gene ID: | 4942 |
| NCBI Accession: | P04181.1 |
| UniProt Secondary Accession: | P04181,Q16068, Q16069, Q68CS0, Q6IAV9, Q9UD03, D3DRF0 |
| UniProt Related Accession: | P04181 |
| Molecular Weight: | 32,853 Da |
| NCBI Full Name: | Ornithine aminotransferase, mitochondrial |
| NCBI Synonym Full Names: | ornithine aminotransferase |
| NCBI Official Symbol: | OAT�� |
| NCBI Official Synonym Symbols: | OKT; GACR; HOGA; OATASE�� |
| NCBI Protein Information: | ornithine aminotransferase, mitochondrial |
| UniProt Protein Name: | Ornithine aminotransferase, mitochondrial |
| UniProt Synonym Protein Names: | Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase |
| UniProt Gene Name: | OAT�� |
| UniProt Entry Name: | OAT_HUMAN |
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