Human OPTC Recombinant Protein (RPPB4163)

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SKU:
RPPB4163
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UBM4

Description

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Product Name:Human OPTC Recombinant Protein
Product Code:RPPB4163
Size:20µg
Species:Human
Target:OPTC
Synonyms:Opticin, Oculoglycan, OPT.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:OPTC protein solution (0.5mg/ml) containing 20mM Tris-HCl(pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSASLPRKE RKRREEQMPR EGDSFEVLPL RNDVLNPDNY GEVIDLSNYEELTDYGDQLP EVKVTSLAPA TSISPAKSTT APGTPSSNPT MTRPTTAGLL LSSQPNHGLP TCLVCVCLGSSVYCDDIDLE DIPPLPRRTA YLYARFNRIS RIRAEDFKGLTKLKRIDLSN NLISSIDNDA FRLLHALQDL ILPENQLEAL PVLPSGIEFLDVRLNRLQSS GIQPAAFRAM EKLQFLYLSD NLLDSIPGPL PLSLRSVHLQ NNLIETMQRD VFCDPEEHKHTRRQLEDIRL DGNPINLSLF PSAYFCLPRL PIGRFT

Opticin also known as OPTC is a member of the class III of the smallleucine-rich� repeat protein (SLRP)family. Members of this family are usually linked with the extracellularmatrix. OPTC is attended in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, opticnerve, choroid, retina, and fetal liver. OPTC might noncovalently bind collagenfibrils and regulate fibril morphology, spacing and organization. OPTC is mappedto a an area of chromosome 1 which is linked with the inherited eye diseasesage-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa(AXPC1).

OPTC Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 336 amino acids (20-332 a.a) and having amolecular mass of 37.6kDa.OPTC is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:OPTC: Binds collagen fibrils. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: proteinaceous extracellular matrix

Molecular Function:extracellular matrix structural constituent

Biological Process: negative regulation of angiogenesis

NCBI Summary:Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq]
UniProt Code:Q9UBM4
NCBI GenInfo Identifier:5777529
NCBI Gene ID:26254
NCBI Accession:
UniProt Secondary Accession:Q9UBM4,Q5T2G4,
UniProt Related Accession:Q9UBM4
Molecular Weight:37,261 Da
NCBI Full Name:opticin
NCBI Synonym Full Names:opticin
NCBI Official Symbol:OPTC��
NCBI Official Synonym Symbols:OPT; OPTC��
NCBI Protein Information:opticin; oculoglycan
UniProt Protein Name:Opticin
UniProt Synonym Protein Names:Oculoglycan
Protein Family:Opticin
UniProt Gene Name:OPTC��
UniProt Entry Name:OPT_HUMAN
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