Human NXT2 Recombinant Protein (RPPB4148)

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RPPB4148

Description

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Product Name:Human NXT2 Recombinant Protein
Product Code:RPPB4148
Size:25µg
Species:Human
Target:NXT2
Synonyms:NTF2-related export protein 2, Protein p15-2, NXT2, BM-025, DC9, P15-2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:NXT2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 40% glycerol and 200mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMRKYRS HWSQGDREGY QRRSNYYEGP HTSHSSPADR TREEVVTPTL PEHTATRSQM ATSLDFKTYV DQACRAAEEF VNIYYETMDK RRRALTRLYL DKATLIWNGN AVSGLDALNN FFDTLPSSEF QVNMLDCQPV HEQATQSQTT VLVVTSGTVKFDGNKQHFFN QNFLLTAQST PNNTVWKIAS DCFRFQDWSS S

Nuclear transport factor 2-like export factor 2 (NXT2) belongs to the NXT family proteins which are commonly involved in exporting nuclear RNA in eukaryotic cells. The NXT2 protein is a regulator of protein export for NES-containing proteins. In addition, NXT2 associates with NXF1, NXF2, NXF3 and NXF5 and has a role in mRNA nuclear export. NXT2 has a critical role in upholding morphogenetic integrity of embryonic heart in vertebrate species. The NXT2 protein contains a nuclear transport factor 2 (NTF2) domain, which has a vital role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus, it may also have a role in mRNA nuclear export.

NXT2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-197 a.a) and having a molecular mass of 25.3kDa.NXT2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.
NCBI Summary:The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
UniProt Code:Q9NPJ8
NCBI GenInfo Identifier:336176110
NCBI Gene ID:55916
NCBI Accession:NP_001229546.1
UniProt Secondary Accession:Q9NPJ8,Q0VAN8, Q5JYV5, Q5JYV6, Q5JYV7, Q9H8U0, Q9NQ64 Q9NRL7, Q9Y3M4, Q9Y3M5, D3DUY1,
UniProt Related Accession:Q9NPJ8
Molecular Weight:Calculated: 12kDa; 16kDa; 21kDa; 22kDaObserved: 16kDa
NCBI Full Name:NTF2-related export protein 2 isoform 2
NCBI Synonym Full Names:nuclear transport factor 2 like export factor 2
NCBI Official Symbol:NXT2��
NCBI Official Synonym Symbols:P15-2��
NCBI Protein Information:NTF2-related export protein 2
UniProt Protein Name:NTF2-related export protein 2
UniProt Synonym Protein Names:Protein p15-2
Protein Family:NTF2-related export protein
UniProt Gene Name:NXT2��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NPJ8
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