Human NUBP1 Recombinant Protein (RPPB4133)

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SKU:
RPPB4133
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P53384

Description

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Product Name:Human NUBP1 Recombinant Protein
Product Code:RPPB4133
Size:20µg
Species:Human
Target:NUBP1
Synonyms:Cytosolic Fe-S cluster assembly factor NUBP1 isoform 1 , NBP,NBP1, NBP35, Nucleotide-binding protein 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:NUBP1 protein solution (1mg/ml) in Phosphate buffered saline (pH7.4),10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEEVPHD CPGADSAQAG RGASCQGCPN QRLCASGAGA TPDTAIEEIKEKMKTVKHKI LVLSGKGGVG KSTFSAHLAH GLAEDENTQI ALLDIDICGP SIPKIMGLEG EQVHQSGSGWSPVYVEDNLG VMSVGFLLSS PDDAVIWRGP KKNGMIKQFL RDVDWGEVDY LIVDTPPGTS DEHLSVVRYLATAHIDGAVI ITTPQEVSLQ DVRKEINFCR KVKLPIIGVV ENMSGFICPK CKKESQIFPP TTGGAELMCQDLEVPLLGRV PLDPLIGKNC DKGQSFFIDA PDSPATLAYR SIIQRIQEFC NLHQSKEENL ISS

Cytosolic Fe-S cluster assembly factor NUBP1 isoform 1 (NUBP1) is Involved in the regulation of centrosome duplication similarity. NUBP1 is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. NUBP1 is necessary for maturation of extra mitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer constructs a Fe-S scaffold complex, mediating the de novo compilation of a Fe-S cluster and its transfer to target apoproteins.

NUBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (1-320 a.a) and having a molecular mass of 36.9kDa.NUBP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques

UniProt Protein Function:NUBP1: Implicated in the regulation of centrosome duplication. Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer 2 labile 4Fe-4S clusters to target apoproteins. Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function:iron-sulfur cluster binding; nucleotide binding; protein binding

Biological Process: cell growth; cellular iron ion homeostasis; iron-sulfur cluster assembly

NCBI Summary:NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]
UniProt Code:P53384
NCBI GenInfo Identifier:257050984
NCBI Gene ID:4682
NCBI Accession:P53384.2
UniProt Secondary Accession:P53384,Q32M30, Q498A9, Q53FS7,
UniProt Related Accession:P53384
Molecular Weight:33,412 Da
NCBI Full Name:Cytosolic Fe-S cluster assembly factor NUBP1
NCBI Synonym Full Names:nucleotide binding protein 1
NCBI Official Symbol:NUBP1��
NCBI Official Synonym Symbols:NBP; NBP1; NBP35��
NCBI Protein Information:cytosolic Fe-S cluster assembly factor NUBP1
UniProt Protein Name:Cytosolic Fe-S cluster assembly factor NUBP1
UniProt Synonym Protein Names:Nucleotide-binding protein 1
Protein Family:Cytosolic Fe-S cluster assembly factor
UniProt Gene Name:NUBP1��
UniProt Entry Name:NUBP1_HUMAN
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