Human NTPDase 2/ENTPD2 Recombinant Protein (RPES0213)
- SKU:
- RPES0213
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human NTPDase 2/ENTPD2 Recombinant Protein
NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants.
| Product Name: | Human NTPDase 2/ENTPD2 Recombinant Protein (RPES0213) |
| Product Code: | RPES0213 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | CD39L1,NTPDase-2,RP11-229P13.11-001 |
| Accession: | Q9Y5L3 |
| Sequence: | Thr 29-Asp460 |
| Fusion tag: | N-His |
| Activity: | Measured by its ability to hydrolyze the 5phosphate groups from the substrate adenosine 5triphosphate(ATP).The specific activity is > 5,000 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mature form of human ENTPD2 (Q9Y5L3) (Thr29-Asp460) was expressed, with a polyhistidine tag at the N-terminus. |
| Purity: | > 85 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 49.3 kDa |
| AP Mol Mass: | 59 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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