Enzymes Recombinant Proteins

Human NTMT1 Recombinant Protein (RPPB2040)

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SKU:
RPPB2040
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BV86
Research Area:
Enzymes

Description

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Product Name:Human NTMT1 Recombinant Protein
Product Code:RPPB2040
Size:10µg
Species:Human
Target:NTMT1
Synonyms:NTMT1, N-Terminal Xaa-Pro-Lys N-Methyltransferase 1, X-Pro-LysN-Terminal Protein Methyltransferase 1A, AlphaN-Terminal Protein Methyltransferase 1A , Methyltransferase-Like Protein 11A , N-Terminal RCC1 Methyltransferase, METTL11A, C9orf32, NTM1A, NRMT, Chromosome 9 OpenReading Frame 32, Methyltransferase Like 11A, EC 2.1.1.244, AD-003, HOMT1A, NRMT1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NTMT1protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15MNaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEFMTSEV IEDEKQFYSK AKTYWKQIPP TVDGMLGGYG HISSIDINSS RKFLQRFLRE GPNKTGTSCA LDCGAGIGRI TKRLLLPLFR EVDMVDITED FLVQAKTYLG EEGKRVRNYF CCGLQDFTPE PDSYDVIWIQ WVIGHLTDQH LAEFLRRCKGSLRPNGIIVI KDNMAQEGVI LDDVDSSVCR DLDVVRRIIC SAGLSLLAEE RQENLPDEIY HVYSFALR

N-terminal Xaa-Pro-Lys N-methyltrasferase1, also known as NTMT1 belongsto the methyltransferase superfamily.

NTMT1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 248 amino acids (1-223 a.a) andhaving a molecular mass of 28.1kDa. NTMT1 is fused to a 25 amino acid His-tagat N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:METTL11A: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Belongs to the methyltransferase superfamily. NTM1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.1.1.244; Methyltransferase, protein N-term; Methyltransferase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:protein methyltransferase activity

Biological Process: N-terminal peptidyl-proline di-methylation; spindle organization and biogenesis; N-terminal peptidyl-alanine tri-methylation; chromosome segregation

NCBI Summary:The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]
UniProt Code:Q9BV86
NCBI GenInfo Identifier:74761281
NCBI Gene ID:28989
NCBI Accession:Q9BV86.3
UniProt Secondary Accession:Q9BV86,Q5SZB9, Q9UI28, A8K4J2, A8K8G7,
UniProt Related Accession:Q9BV86
Molecular Weight:15,896 Da
NCBI Full Name:N-terminal Xaa-Pro-Lys N-methyltransferase 1
NCBI Synonym Full Names:N-terminal Xaa-Pro-Lys N-methyltransferase 1
NCBI Official Symbol:NTMT1��
NCBI Official Synonym Symbols:NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A��
NCBI Protein Information:N-terminal Xaa-Pro-Lys N-methyltransferase 1; N-terminal RCC1 methyltransferase; X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase-like protein 11A
UniProt Protein Name:N-terminal Xaa-Pro-Lys N-methyltransferase 1
UniProt Synonym Protein Names:Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; N-terminal RCC1 methyltransferase; X-Pro-Lys N-terminal protein methyltransferase 1A; NTM1A
Protein Family:N-terminal Xaa-Pro-Lys N-methyltransferase
UniProt Gene Name:NTMT1��
UniProt Entry Name:NTM1A_HUMAN
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