Enzymes Recombinant Proteins

Human NT5C3B Recombinant Protein (RPPB2038)

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SKU:
RPPB2038
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q969T7
Research Area:
Enzymes

Description

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Product Name:Human NT5C3B Recombinant Protein
Product Code:RPPB2038
Size:20µg
Species:Human
Target:NT5C3B
Synonyms:NT5C3L, 7-methylguanosine phosphate-specific5'-nucleotidase, Cytosolic 5'-nucleotidase 3B, Cytosolic 5'-nucleotidaseIII-like protein, cN-III-like protein, N(7)-methylguanylate 5'-phosphatase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NT5C3B protein solution (1mg/ml) containing PhosphateBuffered Saline (pH7.4), 20% glycerol and1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAEEVST LMKATVLMRQ PGRVQEIVGA LRKGGGDRLQ VISDFDMTLSRFAYNGKRCP SSYNILDNSK IISEECRKEL TALLHHYYPI EIDPHRTVKE KLPHMVEWWT KAHNLLCQQKIQKFQIAQVV RESNAMLREG YKTFFNTLYH NNIPLFIFSA GIGDILEEII RQMKVFHPNI HIVSNYMDFNEDGFLQGFKG QLIHTYNKNS SACENSGYFQ QLEGKTNVIL LGDSIGDLTM ADGVPGVQNI LKIGFLNDKVEERRERYMDS YDIVLEKDET LDVVNGLLQH ILCQGVQLEM QGP

7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) includes transferase activity and nucleotide binding. Among NT5C3B�s related super-pathways are adenosine nucleotides degradation II and Pyrimidine metabolism. NT5C3B hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP guards cells against undesired retrieval of m(7)GMP and its incorporation into nucleic acids. In addition, NT5C3B has weak activity for CMP.

NT5C3B Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 323 amino acids (1-300 a.a) and havinga molecular mass of 36.8kDa.NT5C3B is fusedto a 23 amino acid His-tag at N-terminus & purified by proprietarychromatographic techniques.

UniProt Protein Function:NT5C3B: Can act both as nucleotidase and as phosphotransferase. Belongs to the pyrimidine 5'-nucleotidase family.Protein type: EC 3.1.3.5; EC 3.1.3.91; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 17q21.2Cellular Component: cytosolMolecular Function: 5'-nucleotidase activity; protein binding
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q969T7
NCBI GenInfo Identifier:156627549
NCBI Gene ID:115024
NCBI Accession:NP_443167.3
UniProt Secondary Accession:Q969T7
UniProt Related Accession:Q969T7
Molecular Weight:
NCBI Full Name:5'-nucleotidase, cytosolic III-like
NCBI Synonym Full Names:5'-nucleotidase, cytosolic IIIB
NCBI Official Symbol:NT5C3B��
NCBI Official Synonym Symbols:NT5C3L; cN-IIIB��
NCBI Protein Information:7-methylguanosine phosphate-specific 5'-nucleotidase
UniProt Protein Name:7-methylguanosine phosphate-specific 5'-nucleotidase
UniProt Synonym Protein Names:Cytosolic 5'-nucleotidase 3B; Cytosolic 5'-nucleotidase III-like protein
Protein Family:
UniProt Gene Name:NT5C3B��
UniProt Entry Name:5NT3B_HUMAN
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