Enzymes Recombinant Proteins

Human NT5C2 Recombinant Protein (RPPB2037)

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RPPB2037

Description

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Product Name:Human NT5C2 Recombinant Protein
Product Code:RPPB2037
Size:20µg
Species:Human
Target:NT5C2
Synonyms:Cytosolic purine 5'-nucleotidase, Cytosolic 5'-nucleotidase II, NT5C2, NT5B, NT5CP, PNT5, GMP, cN-II.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:NT5C2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.1M NaCl, 1mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSTSWSDRLQ NAADMPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG FDMDYTLAVY KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL VFDTLYGNLL KVDAYGNLLV CAHGFNFIRG PETREQYPNK FIQRDDTERF YILNTLFNLP ETYLLACLVD FFTNCPRYTS CETGFKDGDL FMSYRSMFQD VRDAVDWVHY KGSLKEKTVE NLEKYVVKDG KLPLLLSRMK EVGKVFLATN SDYKYTDKIM TYLFDFPHGP KPGSSHRPWQ SYFDLILVDA RKPLFFGEGT VLRQVDTKTG KLKIGTYTGP LQHGIVYSGG SSDTICDLLG AKGKDILYIG DHIFGDILKS KKRQGWRTFL VIPELAQELH VWTDKSSLFE ELQSLDIFLA ELYKHLDSSS NERPDISSIQ RRIKKVTHDM DMCYGMMGSL FRSGSRQTLF ASQVMRYADL YAASFINLLY YPFSYLFRAA HVLMPHESTV EHTHVDINEM ESPLATRNRT SVDFKDTDYK RHQLTRSISE IKPPNLFPLA PQEITHCHDE DDDEEEEEEE E

NT5C2 (NT5B/PNT5) has a vital role in the maintenance of purine/pyrimidine nucleotides. NT5C2 contains a phosphotransferase active site which catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. Furthermore, NT5C2 regulates the level of inosine monophosphate (IMP) and guanosine monophosphate (GMP) pools inside cells by way of hydrolysis.

NT5C2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 581 amino acids (1-561 a.a.) and having a molecular mass of 67.1kDa.NT5C2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NCBI Summary:This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
UniProt Code:P49902
NCBI GenInfo Identifier:1703012
NCBI Gene ID:22978
NCBI Accession:P49902.1
UniProt Related Accession:P49902
Molecular Weight:
NCBI Full Name:Cytosolic purine 5'-nucleotidase
NCBI Synonym Full Names:5'-nucleotidase, cytosolic II
NCBI Official Symbol:NT5C2��
NCBI Official Synonym Symbols:GMP; NT5B; PNT5; SPG45; SPG65; cN-II��
NCBI Protein Information:cytosolic purine 5'-nucleotidase
UniProt Protein Name:Cytosolic purine 5'-nucleotidase
UniProt Synonym Protein Names:Cytosolic 5'-nucleotidase II
UniProt Gene Name:NT5C2��
UniProt Entry Name:5NTC_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P49902
Research Area:
Enzymes
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