Human NRBF2 Recombinant Protein (RPPB4122)
- SKU:
- RPPB4122
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96F24
Description
| Product Name: | Human NRBF2 Recombinant Protein |
| Product Code: | RPPB4122 |
| Size: | 10µg |
| Species: | Human |
| Target: | NRBF2 |
| Synonyms: | Nuclear receptor binding factor 2, COPR1, COPR2, NRBF-2, Nuclear receptor-binding factor 2, Comodulator of PPAR and RXR, NRBF2, COPR. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NRBF2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMKLTQSE QAHLSLELQR DSHMKQLLLI QERWKRAQRE ERLKAQQNTD KDAAAHLQTS HKPSAEDAEG QSPLSQKYSP STEKCLPEIQ GIFDRDPDTL LYLLQQKSEP AEPCIGSKAP KDDKTIIEEQ ATKIADLKRH VEFLVAENER LRKENKQLKA EKARLLKGPI EKELDVDADF VETSELWSLP PHAETATASS TWQKFAANTG KAKDIPIPNL PPLDFPSPEL PLMELSEDIL KGFMNN |
Nuclear receptor binding factor 2 (NRBF2) which works as transcriptional activator, modulates transcriptional activation by target nuclear receptors.
NRBF2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 266 amino acids (45-287) and having a molecular mass of 29.9 kDa.NRBF2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NRBF2: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand. Detected in keratinocytes, liver and placenta. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Autophagy; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 10q21.3 Cellular Component: nucleoplasm; cytoplasm Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; gene expression |
| UniProt Code: | Q96F24 |
| NCBI GenInfo Identifier: | 74731648 |
| NCBI Gene ID: | 29982 |
| NCBI Accession: | Q96F24.1 |
| UniProt Secondary Accession: | Q96F24,Q86UR2, Q96NP6, Q9H0S9, Q9H2I2, A6PW36, B4DWS0 |
| UniProt Related Accession: | Q96F24 |
| Molecular Weight: | 287 |
| NCBI Full Name: | Nuclear receptor-binding factor 2 |
| NCBI Synonym Full Names: | nuclear receptor binding factor 2 |
| NCBI Official Symbol: | NRBF2�� |
| NCBI Official Synonym Symbols: | COPR1; COPR2; NRBF-2�� |
| NCBI Protein Information: | nuclear receptor-binding factor 2; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; nuclear receptor binding factor-2 |
| UniProt Protein Name: | Nuclear receptor-binding factor 2 |
| UniProt Synonym Protein Names: | Comodulator of PPAR and RXR |
| Protein Family: | Nuclear receptor-binding factor |
| UniProt Gene Name: | NRBF2�� |
| UniProt Entry Name: | NRBF2_HUMAN |
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