Enzymes Recombinant Proteins
Human NQO2 Recombinant Protein (RPPB2036)
- SKU:
- RPPB2036
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P16083
- Research Area:
- Enzymes
Description
| Product Name: | Human NQO2 Recombinant Protein |
| Product Code: | RPPB2036 |
| Size: | 25µg |
| Species: | Human |
| Target: | NQO2 |
| Synonyms: | DHQV, DIA6, QR2, EC 1.10.99.2, NMOR2, NQO2, NRH:quinone oxidoreductase 2, NRH dehydrogenase [quinone] 2, Ribosyldihydronicotinamide dehydrogenase [quinone]. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | NQO2 Human solution (1mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q |
NQO2 is a flavoprotein that catalyzes the 2-electron reduction of diverse quinones, redox dyes, and the vitamin K menadione. NQO2 mainly uses dihydronicotinamide riboside (NRH) as the electron donor. NQO2 catalyzes the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity.
NQO2 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 251amino acids (1-231 a.a.) and having a molecular mass of 28.1 kDa. NQO2 protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.
| UniProt Protein Function: | NQO2: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Belongs to the NAD(P)H dehydrogenase (quinone) family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.10.99.2 Chromosomal Location of Human Ortholog: 6p25.2 Cellular Component: nucleoplasm; cytoplasm Molecular Function:electron carrier activity; dihydronicotinamide riboside quinone reductase activity; NADPH dehydrogenase (quinone) activity; metal ion binding Biological Process: memory Disease: Breast Cancer |
| NCBI Summary: | This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| UniProt Code: | P16083 |
| NCBI GenInfo Identifier: | 317373581 |
| NCBI Gene ID: | 4835 |
| NCBI Accession: | P16083.5 |
| UniProt Secondary Accession: | P16083,Q9JI75, |
| UniProt Related Accession: | P16083 |
| Molecular Weight: | 231 |
| NCBI Full Name: | Ribosyldihydronicotinamide dehydrogenase |
| NCBI Synonym Full Names: | NAD(P)H dehydrogenase, quinone 2 |
| NCBI Official Symbol: | NQO2�� |
| NCBI Official Synonym Symbols: | QR2; DHQV; DIA6; NMOR2�� |
| NCBI Protein Information: | ribosyldihydronicotinamide dehydrogenase [quinone]; ribosyldihydronicotinamide dehydrogenase [quinone]; quinone reductase 2; NRH:quinone oxidoreductase 2; NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2 |
| UniProt Protein Name: | Ribosyldihydronicotinamide dehydrogenase [quinone] |
| UniProt Synonym Protein Names: | NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Quinone reductase 2; QR2 |
| Protein Family: | NADH-quinone oxidoreductase |
| UniProt Gene Name: | NQO2�� |
| UniProt Entry Name: | NQO2_HUMAN |
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