Human NOL3 Recombinant Protein (RPPB4116)
- SKU:
- RPPB4116
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O60936
Description
| Product Name: | Human NOL3 Recombinant Protein |
| Product Code: | RPPB4116 |
| Size: | 20µg |
| Species: | Human |
| Target: | NOL3 |
| Synonyms: | Nucleolar protein 3 (apoptosis repressor with CARD domain), Muscle-enriched cytoplasmic protein, Nucleolar protein of 30 kDa, Apoptosis repressor with CARD, nucleolar protein 3, NOP30, CARD2, ARC, NOP, MYP, MYC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NOL3 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT, 1mM EDTA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGNAQER PSETIDRERK RLVETLQADS GLLLDALLAR GVLTGPEYEA LDALPDAERR VRRLLLLVQG KGEAACQELL RCAQRTAGAP DPAWDWQHVG PGYRDRSYDP PCPGHWTPEA PGSGTTCPGL PRASDPDEAG GPEGSEAVQS GTPEEPEPEL EAEASKEAEP EPEPEPELEP EAEAEPEPEL EPEPDPEPEP DFEERDESED S |
Nucleolar protein 3 (NOL3) is primarily expressed in the muscle and is appears in the nucleoplasm and concentrated in nucleoli. NOL3 is an anti-apoptotic protein which down-regulates the enzymatic activities of caspase 2, caspase 8 and tumor protein p53. NOL3 is highly expressed in the heart and skeletal muscle. NOL3 is identified at low levels in the placenta, liver, kidney and pancreas. The NOL3 mRNA and protein levels are stimulated by neuronal activity, which is vital in order to promote neuroplasticity, thus indicating a potential role for NOL3 in activity-dependent changes in dendrite function. NOL3 localizes to the cytoskeleton of neuronal cells and seems to colocalize with F-Actin, though it may connect with an actin-associated protein instead of directly with F-Actin.
NOL3 Human Recombinant produced in E. coli is a single polypeptide chain containing 231 amino acids (1-208) and having a molecular mass of 25.0 kDa.NOL3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Isoform 1: May be involved in RNA splicing. |
| NCBI Summary: | This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Code: | O60936 |
| NCBI GenInfo Identifier: | 20455079 |
| NCBI Gene ID: | 8996 |
| NCBI Accession: | O60936.1 |
| UniProt Secondary Accession: | O60936,O60937, B4DFL0, |
| UniProt Related Accession: | O60936 |
| Molecular Weight: | 29,355 Da |
| NCBI Full Name: | Nucleolar protein 3 |
| NCBI Synonym Full Names: | nucleolar protein 3 (apoptosis repressor with CARD domain) |
| NCBI Official Symbol: | NOL3�� |
| NCBI Official Synonym Symbols: | ARC; FCM; MYP; NOP; NOP30�� |
| NCBI Protein Information: | nucleolar protein 3; nucleolar protein of 30 kDa; muscle-enriched cytoplasmic protein |
| UniProt Protein Name: | Nucleolar protein 3 |
| UniProt Synonym Protein Names: | Apoptosis repressor with CARD; Muscle-enriched cytoplasmic protein; Myp; Nucleolar protein of 30 kDa; Nop30 |
| Protein Family: | Nucleolar protein |
| UniProt Gene Name: | NOL3�� |
| UniProt Entry Name: | NOL3_HUMAN |
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