Human NMI Recombinant Protein (RPPB4112)

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RPPB4112

Description

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Product Name:Human NMI Recombinant Protein
Product Code:RPPB4112
Size:20µg
Species:Human
Target:NMI
Synonyms:N-myc (and STAT) Interactor.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The NMI protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQLK KEIQKLETE LQEATKEFQI KEDIPETKMK FLSVETPEND SQLSNISCSF QVSSKVPYEI QKGQALITFE KEEVAQNVVS MSKHHVQIKDV NLEVTAKPV PLNSGVRFQV YVEVSKMKIN VTEIPDTLRE DQMRDKLELS FSKSRNGGGE VDRVDYDRQS GSAVITFVEI GVADKILKKKEYPLYINQTC HRVTVSPYTE IHLKKYQIFS GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP HIAYFEE

N-myc-interactor belongs to the oncogene Myc family which has a significant part in cell proliferation, differentiation, and neoplastic transformation. In Addition, NMI cooperates with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA is expressed in small quantities in all human fetal and adult tissues tested except brain and but in large quantities in cancer cell line-myeloid leukemias.

NMI produced in E.Coli is a single, non-glycosylated polypeptide chain containing 327 amino acids (1-307a.a.) and having a molecular mass of 37.2kDa.NMI is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NMI: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. Belongs to the NMI family.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q23.3

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function:identical protein binding; protein binding

Biological Process: inflammatory response; JAK-STAT cascade

NCBI Summary:NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
UniProt Code:Q13287
NCBI GenInfo Identifier:116242679
NCBI Gene ID:9111
NCBI Accession:Q13287.2
UniProt Secondary Accession:Q13287,Q53TI8, Q8WTW2, Q9BVE5, B5BU69,
UniProt Related Accession:Q13287
Molecular Weight:35kDa
NCBI Full Name:N-myc-interactor
NCBI Synonym Full Names:N-myc and STAT interactor
NCBI Official Symbol:NMI��
NCBI Protein Information:N-myc-interactor
UniProt Protein Name:N-myc-interactor
UniProt Synonym Protein Names:N-myc and STAT interactor
Protein Family:N-myc-interactor
UniProt Gene Name:NMI��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q13287
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