Human NMB Recombinant Protein (RPPB4104)

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RPPB4104

Description

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Product Name:Human NMB Recombinant Protein
Product Code:RPPB4104
Size:10µg
Species:Human
Target:NMB
Synonyms:Neuromedin-B, NMB, Neuromedin-B-32, Neuromedin B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NMB solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSAPLSWDL PEPRSRASKI RVHSRGNLWA TGHFMGKKSL EPSSPSPLGT APHTSLRDQR LQLSHDLLGI LLLKKALGVS LSRPAPQIQY RRLLVQILQK

Neuromedin B (NMB) which is a part of the bombesin/neuromedin-B/ranatensin family and stimulates smooth muscle contraction in a way similar to that of bombesin.

NMB Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (25-121) and having a molecular mass of 13.2 kDa.NMB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NMB: Stimulates smooth muscle contraction in a manner similar to that of bombesin. Belongs to the bombesin/neuromedin-B/ranatensin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q25.2

Cellular Component: extracellular region

Molecular Function:hormone activity; protein binding

Biological Process: cell-cell signaling; signal transduction

NCBI Summary:This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
UniProt Code:P08949
NCBI GenInfo Identifier:281185514
NCBI Gene ID:4828
NCBI Accession:P08949.4
UniProt Secondary Accession:P08949,Q96A06, Q96HH5,
UniProt Related Accession:P08949
Molecular Weight:13kDa
NCBI Full Name:Neuromedin-B
NCBI Synonym Full Names:neuromedin B
NCBI Official Symbol:NMB��
NCBI Protein Information:neuromedin-B
UniProt Protein Name:Neuromedin-B
Protein Family:Neuromedin
UniProt Gene Name:NMB��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P08949
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