Human NKIRAS2 Recombinant Protein (RPPB4100)

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SKU:
RPPB4100
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NYR9

Description

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Product Name:Human NKIRAS2 Recombinant Protein
Product Code:RPPB4100
Size:10µg
Species:Human
Target:NKIRAS2
Synonyms:NF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2, KappaB-Ras2, NKIRAS2, KBRAS2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NKIRAS2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQ VRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQE QRRVDPDVAQ HWAKSEKVKL WEVSVADRRSLLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG

NFKB inhibitor interacting Ras-like 2 (NKIRAS2) is an inhibitor of the transcription factor NF-kappaB. NKIRAS2 is similar to the Ras-like small GTPases which associate with IkappaB. NKIRAS2 is an atypical Ras-like protein which functions as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more impervious to degradation.

NKIRAS2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 215 amino acids (1-191 a.a) and having a molecular mass of 24kDa.NKIRAS2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NKIRAS2: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric, Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 17q21.2
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9NYR9
NCBI GenInfo Identifier:74734716
NCBI Gene ID:28511
NCBI Accession:Q9NYR9.1
UniProt Secondary Accession:Q9NYR9,Q6PK52, Q96KC7, Q9NSX1, A6NCZ5, B3KNN0, B4DNM3
UniProt Related Accession:Q9NYR9
Molecular Weight:10,770 Da
NCBI Full Name:NF-kappa-B inhibitor-interacting Ras-like protein 2
NCBI Synonym Full Names:NFKB inhibitor interacting Ras like 2
NCBI Official Symbol:NKIRAS2��
NCBI Official Synonym Symbols:KBRAS2; kappaB-Ras2��
NCBI Protein Information:NF-kappa-B inhibitor-interacting Ras-like protein 2
UniProt Protein Name:NF-kappa-B inhibitor-interacting Ras-like protein 2
UniProt Synonym Protein Names:I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2
Protein Family:NF-kappa-B inhibitor-interacting Ras-like protein
UniProt Gene Name:NKIRAS2��
UniProt Entry Name:KBRS2_HUMAN
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