Immune Checkpoint Recombinant Proteins
Human NKG2D Recombinant Protein (mFc Tag) (HDPT0061)
(No reviews yet)
Write a Review
- SKU:
- HDPT0061
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immune Checkpoint
Description
Human NKG2D Recombinant Protein (mFc Tag)
| Description: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. |
| Product name: | Human NKG2D Recombinant Protein (mFc Tag) |
| Synonyms: | NKG2D,CD314,KLRK1,NK cell receptor D |
| Type: | protein |
| Size: | 50 µg |
| Name: | NKG2D |
| Origin: | Human |
| Source: | HEK293 |
| Protein Type: | Recombinant |
| Application: | Contact Technical Support |
| Purity: | > 95% |
| Purification: | affinity purification |
| Format: | Lyophilized |
| Conjugate: | N-Mouse Fc |
| Storage: | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage: | Research use only |
| Buffer: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Reconstitution: | Reconstitute with deionized water |
| Sequence: | mFc（Pro99-Lys330）+NKG2D（Ile73-Val216） |
| Gene ID: | 574240 |
| Uniprot: | P26718 |
| Molecular Weight: | 42.8 kDa |
Related Products
Human CLDN6 Recombinant Protein (mFc Tag) (HDPT0050)
Immune Checkpoint Recombinant Proteins
Human CLDN6 Recombinant Protein (mFc Tag)Description:Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and...
Human NKG2D/CD314 Recombinant Protein (RPES0868)
Immunology Recombinant Proteins
system_update_altDatasheetHuman NKG2D/CD314 Recombinant Protein NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG
Human ACE2 Recombinant Protein (mFc Tag) (HDPT0057)
Immune Checkpoint Recombinant Proteins
Human ACE2 Recombinant Protein (mFc Tag)Description:The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable...
Human TweakR Recombinant Protein (mFc Tag) (HDPT0077)
Immune Checkpoint Recombinant Proteins
Human TweakR Recombinant Protein (mFc Tag)Description:TNFRSF12A (TNF Receptor Superfamily Member 12A) is a Protein Coding gene. Diseases associated with TNFRSF12A include Multiple...
Human PSMA Recombinant Protein (mFc Tag) (HDPT0193)
Immune Checkpoint Recombinant Proteins
Human PSMA Recombinant Protein (mFc Tag)Description:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on...
Human BCMA Recombinant Protein (mFc Tag) (HDPT0035)
Immune Checkpoint Recombinant Proteins
Human BCMA Recombinant Protein (mFc Tag)Description:B-cell maturation protein (BCMA or BCM), is also known as Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), which is encoded by the...
Human CD52 Recombinant Protein (mFc Tag) (HDPT0112)
Immune Checkpoint Recombinant Proteins
Human CD52 Recombinant Protein (mFc Tag)Description:CD52 (CD52 Molecule) is a Protein Coding gene. Diseases associated with CD52 include Prolymphocytic Leukemia and Lymphocytic...
Human NKG2D/CD314 Recombinant Protein (RPES1913)
system_update_altDatasheetHuman NKG2D/CD314 Recombinant Protein NKG2D, also known as CD314, is an immune receptor which consists of two disulphide-linked type II transmembrane proteins with short
Human AXL Recombinant Protein (mFc Tag) (HDPT0180)
Immune Checkpoint Recombinant Proteins
Human AXL Recombinant Protein (mFc Tag)Description:The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an...