Immunology Recombinant Proteins

Human NKG2D/CD314 Recombinant Protein (RPES3681)

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RPES3681

Description

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Human NKG2D/CD314 Recombinant Protein

NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells; CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor; it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells; leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx; culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA; MICB; RAET1E; RAET1G; ULBP1; ULBP2; ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Product Name:Human NKG2D/CD314 Recombinant Protein (RPES3681)
Product Code:RPES3681
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:CD314, KLRK1,CD314 antigen,Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K, member 1, KLR, NK cell receptor D, NKG2-D, NKG2-D type II integral membrane protein, NKG2-D-activating NK recepto
Accession:P26718
Sequence:Phe78-Val216
Fusion tag:N-6His
Activity:Immobilized Human NKG2D-His at 10µg/ml(100 ?l/well) can bind Human MICA-Fc(Cat: PKSH032753). The ED50 of Human NKG2D-His is 19.8 ug/ml .
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human NKG2-D type II Integral Membrane Protein is produced by our Mammalian expression system and the target gene encoding Phe78-Val216 is expressed with a 6His tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:16.9 kDa
AP Mol Mass:20-30 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
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