Human NKG2D/CD314 Recombinant Protein (RPES1913)

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SKU:
RPES1913
Product Type:
Recombinant Protein
Species:
Human

Description

system_update_altDatasheet

Human NKG2D/CD314 Recombinant Protein

NKG2D, also known as CD314, is an immune receptor which consists of two disulphide-linked type II transmembrane proteins with short intracellular proteins uncapable to transduce signals. In order to transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.

Product Name:Human NKG2D/CD314 Recombinant Protein (RPES1913)
Product Code:RPES1913
Size:50µg
Species:Human
Expressed Host:Baculovirus-Insect Cells
Synonyms:CD314, KLRK1,CD314 antigen,Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K, member 1, KLR, NK cell receptor D, NKG2-D, NKG2-D type II integral membrane protein, NKG2-D-activating NK recepto
Accession:NP_031386.2
Sequence:Phe78-Val216
Fusion tag:N-His
Activity:1. Immobilized human His-NKG2D (78-216) at 10 µg/ml (100 ?l/well) can bind human ULBP1-Fch, The EC50 of human ULBP1-Fch is 0.04-0.08 µg/ml.2. Immobilized human His-NKG2D (78-216) at 10 µg/ml (100 ?l/well) can bind human MICB-Fch, The EC50 of human MICB-Fch is 15.9-37.1 ng/ml.
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human NKG2D (Phe78-Val216) was fused with a polyhistide tag at the N-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:18.4 kDa
Formulation:Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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