Human NIPSNAP1 Recombinant Protein (RPPB4098)

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SKU:
RPPB4098
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BPW8

Description

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Product Name:Human NIPSNAP1 Recombinant Protein
Product Code:RPPB4098
Size:20µg
Species:Human
Target:NIPSNAP1
Synonyms:Nipsnap Homolog 1 (C. Elegans), 4 Nitrophenylphosphatase Domain And Non-Neuronal SNAP25-Like 1, NIPSNAP, C. Elegans, Homolog, Protein NipSnap Homolog 1, NipSnap1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:NIPSNAP1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAPRLCS ISVTARRLLG GPGPRAGDVA SAAAARFYSK DNEGSWFRSL FVHKVDPRKD AHSTLLSKKE TSNLYKIQFH NVKPEYLDAY NSLTEAVLPK LHLDEDYPCS LVGNWNTWYG EQDQAVHLWR FSGGYPALMD CMNKLKNNKE YLEFRRERSQMLLSRRNQLL LEFSFWNEPQ PRMGPNIYEL RTYKLKPGTM IEWGNNWARA IKYRQENQEA VGGFFSQIGE LYVVHHLWAY KDLQSREETR NAAWRKRGWD ENVYYTVPLV RHMESRIMIP LKISPLQ

NipsnapHomolog 1 (NIPSNAP1) belongs to the NipSnap family. NIPSNAP1 may take part invesicular transport. A similar protein in mice inhibits the calciumchannel TRPV6, and it is localized to the inner mitochondrial membraneas well, where it may be involved in mitochondrial DNA maintenance. Apseudogene of NIPSNAP1 is located on the short arm ofchromosome 17. Among the diseases associated with NIPSNAP1 are maple syrupurine disease, and phenylketonuria.

NIPSNAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (1-284a.a) and having a molecular mass of 35.7kDa.NIPSNAP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NIPSNAP1: a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: mitochondrion; mitochondrial inner membrane

Molecular Function:neurotransmitter binding

Biological Process: sensory perception of pain

NCBI Summary:This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
UniProt Code:Q9BPW8
NCBI GenInfo Identifier:193211616
NCBI Gene ID:8508
NCBI Accession:NP_003625
UniProt Secondary Accession:Q9BPW8,O43800, B2RAY3,
UniProt Related Accession:Q9BPW8
Molecular Weight:33,310 Da
NCBI Full Name:protein NipSnap homolog 1 isoform 1
NCBI Synonym Full Names:nipsnap homolog 1 (C. elegans)
NCBI Official Symbol:NIPSNAP1��
NCBI Protein Information:protein NipSnap homolog 1
UniProt Protein Name:Protein NipSnap homolog 1
Protein Family:Protein
UniProt Gene Name:NIPSNAP1��
UniProt Entry Name:NIPS1_HUMAN
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