Cell Death Recombinant Proteins

Human NGAL/Lipocalin-2 Recombinant Protein (RPES0435)

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SKU:
RPES0435
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death

Description

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Human NGAL/Lipocalin-2 Recombinant Protein

LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. LCN2 binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. LCN2 is involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth.

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