Human NFE2L2 Recombinant Protein (RPPB4087)

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SKU:
RPPB4087
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16236

Description

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Product Name:Human NFE2L2 Recombinant Protein
Product Code:RPPB4087
Size:10µg
Species:Human
Target:NFE2L2
Synonyms:NFE2L2, Nuclear factor erythroid 2-related factor 2, NF-E2-relatedfactor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2,like 2, NRF2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:NFE2L2 protein solution (0.25mg/ml) in Phosphate buffersaline (pH 7.4) containing 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSHMMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE QLQKEQEKAF FAQLQLDEETGEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM QLLAQTFPFV DDNEVSSATF QSLVPDIPGHIESPVFIATN QAQSPETSVA QVAPVDLDGM QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKLTEVDNYHFYS SIPSMEKEVG NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFIAEPSISNSMP SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHSVESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA QCENTPEKEL PVSPGHRKTPFTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD FNEMMSKEQF NEAQLALIRD IRRRGKNKVAAQNCRKRKLE NIVELEQDLD HLKDEKEKLL KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGNVFLVPKSKKP DVKKN

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is bZIP transcription factors which heterodimerize with Maf proteins to bind Mare sequences. In addition, the NRF proteins bind the antioxidant response element (ARE) and are associated with the regulation of detoxification enzymes and the oxidative stress response. NRF2 is extensively expressed and is assumed to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1.

NFE2L2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 625 amino acids (1-605 a.a) and having a molecular mass of 69.9kDa.NFE2L2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: centrosome; cytoplasm; cytosol; nucleus; plasma membrane

Molecular Function:DNA binding; protein binding; protein domain specific binding; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; transcription from RNA polymerase II promoter; unfolded protein response

NCBI Summary:This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
UniProt Code:Q16236
NCBI GenInfo Identifier:25453452
NCBI Gene ID:4780
NCBI Accession:Q16236.3
UniProt Secondary Accession:Q16236,Q53RW6, Q59HH2, Q96F71, B2RBU2, B4E338, E9PGJ7
UniProt Related Accession:Q16236
Molecular Weight:65,356 Da
NCBI Full Name:Nuclear factor erythroid 2-related factor 2
NCBI Synonym Full Names:nuclear factor, erythroid 2 like 2
NCBI Official Symbol:NFE2L2��
NCBI Official Synonym Symbols:NRF2; HEBP1��
NCBI Protein Information:nuclear factor erythroid 2-related factor 2
UniProt Protein Name:Nuclear factor erythroid 2-related factor 2
UniProt Synonym Protein Names:HEBP1; Nuclear factor, erythroid derived 2, like 2
UniProt Gene Name:NFE2L2��
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