Neurotrophins Recombinant Proteins
Human Neuritin/NRN1 Recombinant Protein (RPES2033)
- SKU:
- RPES2033
Description
Human Neuritin/NRN1 Recombinant Protein
Neuritin 1 (NRN1) is a member of neuritin family. Neuritin is a glycosylphosphatidylinositol- anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF; nerve growth factor (NGF) and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. Thus; neuritin is considered as a downstream effector of activity-induced neurite outgrowth. In clinical; neuritin levels in diabetes were reduced in both dorsal root ganglia and sciatic nerve of rats; and these deficits were reversed in vivo by treatment with NGF. This manipulation of neuritin levels in diabetes may provide a potential target for the therapeutic intervention in the management of neuropathy.
| Product Name: | Human Neuritin/NRN1 Recombinant Protein (RPES2033) |
| Product Code: | RPES2033 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | dJ380B8.2,MGC44811,NRN |
| Accession: | Q9NPD7 |
| Sequence: | Met 1-Asn 115 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mature form of human NRN1 (Q9NPD7) (Met 1-Asn 115) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 85 % as determined by reducing SDS-PAGE. |
| AP Mol Mass: | 11 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris; 500mM NaCl; pH 8.0; 10% gly |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Neurotrophins |
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