Enzymes Recombinant Proteins

Human NEK7 Recombinant Protein (RPPB2589)

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SKU:
RPPB2589
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8TDX7
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human NEK7 Recombinant Protein
Product Code:RPPB2589
Size:20µg
Species:Human
Target:NEK7
Synonyms:NIMA (never in mitosis gene a)-related kinase 7, Serine/threonine-protein kinase Nek7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The NEK7 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) , 0.15M NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMDEQSQ GMQGPPVPQF QPQKALRPDM GYNTLANFRI EKKIGRGQFS EVYRAACLLD GVPVALKKVQ IFDLMDAKAR ADCIKEIDLL KQLNHPNVIK YYASFIEDNE LNIVLELADA GDLSRMIKHF KKQKRLIPER TVWKYFVQLC SALEHMHSRR VMHRDIKPAN VFITATGVVK LGDLGLGRFF SSKTTAAHSL VGTPYYMSPE RIHENGYNFK SDIWSLGCLL YEMAALQSPF YGDKMNLYSL CKKIEQCDYP PLPSDHYSEE LRQLVNMCIN PDPEKRPDVT YVYDVAKRMH ACTASS

NEK7, protein kinase, has a vital role in mitotic cell cycle progression. It is essential for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. NEK7 is greatly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen.

NEK7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 326 amino acids (1-302 a.a) and having a molecular mass of 37kDa.NEK7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NEK7: a protein kinase of the NEK family. Phosphorylates and activates p70S6 kinase.Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; NEK familyChromosomal Location of Human Ortholog: 1q31.3Cellular Component: cytoplasm; microtubule; microtubule organizing center; nucleoplasm; spindle poleMolecular Function: ATP binding; metal ion binding; protein serine/threonine kinase activityBiological Process: cytokinesis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid phosphorylation; regulation of mitotic cell cycle; spindle assembly
UniProt Protein Details:
NCBI Summary:NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
UniProt Code:Q8TDX7
NCBI GenInfo Identifier:37537965
NCBI Gene ID:140609
NCBI Accession:Q8TDX7.1
UniProt Secondary Accession:Q8TDX7,A6NGT8
UniProt Related Accession:Q8TDX7
Molecular Weight:13,402 Da
NCBI Full Name:Serine/threonine-protein kinase Nek7
NCBI Synonym Full Names:NIMA related kinase 7
NCBI Official Symbol:NEK7��
NCBI Official Synonym Symbols:
NCBI Protein Information:serine/threonine-protein kinase Nek7
UniProt Protein Name:Serine/threonine-protein kinase Nek7
UniProt Synonym Protein Names:Never in mitosis A-related kinase 7; NimA-related protein kinase 7
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:NEK7��
UniProt Entry Name:NEK7_HUMAN
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system_update_altDatasheetHuman NEK7 Recombinant Protein NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase sup