Human NECTIN3 Recombinant Protein (RPPB4082)
- SKU:
- RPPB4082
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NQS3
Description
| Product Name: | Human NECTIN3 Recombinant Protein |
| Product Code: | RPPB4082 |
| Size: | 5µg |
| Species: | Human |
| Target: | NECTIN3 |
| Synonyms: | Nectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3, CD113, PVRL3, PRR3, NECTIN-3, PVRR3, PPR3.� |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | NECTIN3 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GPIIVEPHVT AVWGKNVSLK CLIEVNETIT QISWEKIHGK SSQTVAVHHP QYGFSVQGEY QGRVLFKNYS LNDATITLHN IGFSDSGKYI CKAVTFPLGN AQSSTTVTVL VEPTVSLIKG PDSLIDGGNE TVAAICIAAT GKPVAHIDWE GDLGEMESTT TSFPNETATI ISQYKLFPTR FARGRRITCV VKHPALEKDI RYSFILDIQY APEVSVTGYD GNWFVGRKGV NLKCNADANP PPFKSVWSRL DGQWPDGLLA SDNTLHFVHP LTFNYSGVYI CKVTNSLGQR SDQKVIYISD PPTTTTLQPT IQWHPSTADI EDLATEPKKL PFPLSTLATI KDDTIATLEH HHHHH |
NECTIN3, also known as Nectin Cell Adhesion Molecule 3, is part of the nectin family. NECTIN3 is intended to initiate cell-cell adhesion to stimulate cell attachment and to allow subsequent formation of JAM-and cadherin-based intercellular junctions. NECTIN3 induces endocytosis-mediated down-regulation of PVR from the cell surface, which results in reduction of cell movement & proliferation. Following Nectin-3 activity adds strength to the junction through trans-interaction with various molecules.�
NECTIN3 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 355 amino acids (58-404 a.a.) and having a molecular mass of 39.1kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).NECTIN3 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PVRL3: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 3q13 Cellular Component: cell-cell adherens junction; integral to plasma membrane; plasma membrane Molecular Function:cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion |
| NCBI Summary: | This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9NQS3 |
| NCBI GenInfo Identifier: | 74762752 |
| NCBI Gene ID: | 25945 |
| NCBI Accession: | Q9NQS3.1 |
| UniProt Secondary Accession: | Q9NQS3,Q6NVZ3, Q8NC05, Q8WVU4, Q9BVA9, Q9Y412, E9PFR0 |
| UniProt Related Accession: | Q9NQS3 |
| Molecular Weight: | 54,375 Da |
| NCBI Full Name: | Nectin-3 |
| NCBI Synonym Full Names: | nectin cell adhesion molecule 3 |
| NCBI Official Symbol: | NECTIN3�� |
| NCBI Official Synonym Symbols: | PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3�� |
| NCBI Protein Information: | nectin-3 |
| UniProt Protein Name: | Nectin-3 |
| UniProt Synonym Protein Names: | CDw113; Nectin cell adhesion molecule 3 |
| UniProt Gene Name: | NECTIN3�� |
| UniProt Entry Name: | NECT3_HUMAN |
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