Human NECAP2 Recombinant Protein (RPPB4079)
- SKU:
- RPPB4079
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NVZ3
Description
| Product Name: | Human NECAP2 Recombinant Protein |
| Product Code: | RPPB4079 |
| Size: | 20µg |
| Species: | Human |
| Target: | NECAP2 |
| Synonyms: | NECAP endocytosis-associated protein 2, NECAP-2, FLJ10420, Adaptin ear-binding coat-associated protein 2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The NECAP2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 2mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEESGYESVL CVKPDVHVYR IPPRATNRGY RAAEWQLDQP SWSGRLRITA KGQMAYIKLE DRTSGELFAQ APVDQFPGTA VESVTDSSRY FVIRIEDGNG RRAFIGIGFG DRGDAFDFNV ALQDHFKWVK QQCEFAKQAQ NPDQGPKLDL GFKEGQTIKL NIANMKKKEG AAGNPRVRPA STGGLSLLPP PPGGKTSTLI PPPGEQLAVG GSLVQPAVAP SSGGAPVPWP QPNPATADIW GDFTKSTGST SSQTQPGTGW VQF |
NECAP2 which is involved in endocytosis, is a vital protein paralogues for clathrin-mediated membrane trafficking which are enhanced in CCV layers.
NECAP2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 283 amino acids (1-263a.a.) and having a molecular mass of 30.5 kDa. NECAP2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NECAP2: Involved in endocytosis. Belongs to the NECAP family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: clathrin vesicle coat; plasma membrane; coated pit; intracellular Biological Process: protein transport; endocytosis |
| NCBI Summary: | This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9NVZ3 |
| NCBI GenInfo Identifier: | 8922416 |
| NCBI Gene ID: | 55707 |
| NCBI Accession: | NP_060560.1 |
| UniProt Secondary Accession: | Q9NVZ3,Q5VSU4, Q5VSU5, Q9H7L1, Q9H8L1, B4DY19, E9PGQ8 |
| UniProt Related Accession: | Q9NVZ3 |
| Molecular Weight: | 25,267 Da |
| NCBI Full Name: | adaptin ear-binding coat-associated protein 2 isoform 1 |
| NCBI Synonym Full Names: | NECAP endocytosis associated 2 |
| NCBI Official Symbol: | NECAP2�� |
| NCBI Protein Information: | adaptin ear-binding coat-associated protein 2; NECAP-2; NECAP endocytosis-associated protein 2; adaptin-ear-binding coat-associated protein 2 |
| UniProt Protein Name: | Adaptin ear-binding coat-associated protein 2 |
| UniProt Synonym Protein Names: | NECAP endocytosis-associated protein 2; NECAP-2 |
| Protein Family: | Adaptin ear-binding coat-associated protein |
| UniProt Gene Name: | NECAP2�� |
| UniProt Entry Name: | NECP2_HUMAN |
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