Enzymes Recombinant Proteins

Human NDUFS5 Recombinant Protein (RPPB2014)

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SKU:
RPPB2014
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43920
Research Area:
Enzymes

Description

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Product Name:Human NDUFS5 Recombinant Protein
Product Code:RPPB2014
Size:25µg
Species:Human
Target:NDUFS5
Synonyms:CI-15k, CI15K, NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, Complex I-15 kDa, NADH-ubiquinone oxidoreductase 15 kDa subunit, CI-15 kDa, NDUFS5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NDUFS5 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPFLDIQ KRFGLNIDRW LTIQSGEQPY KMAGRCHAFE KEWIECAHGI GYTRAEKECK IEYDDFVECL LRQKTMRRAG TIRKQRDKLI KEGKYTPPPH HIGKGEPRP

Histidine NADH Dehydrogenase Fe-S Protein 5 (NDUFS5) belongs to the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. NDUFS5 is a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which doesn�t take part in catalysis. Complex I is transferring the electrons from NADH to the respiratory chain.

NDUFS5 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 129 amino acids (1-106a.a) and having a molecular mass of 14.9kDa. NDUFS5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NDUFS5: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFS5 subunit family.
UniProt Protein Details:

Protein type:Energy Metabolism - oxidative phosphorylation; Mitochondrial

Chromosomal Location of Human Ortholog: 1p34.2-p33

Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; mitochondrion

Molecular Function:NADH dehydrogenase (ubiquinone) activity

Biological Process: cellular metabolic process; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly

NCBI Summary:This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]
UniProt Code:O43920
NCBI GenInfo Identifier:3914138
NCBI Gene ID:4725
NCBI Accession:O43920.3
UniProt Related Accession:O43920
Molecular Weight:12,518 Da
NCBI Full Name:NADH dehydrogenase
NCBI Synonym Full Names:NADH:ubiquinone oxidoreductase subunit S5
NCBI Official Symbol:NDUFS5��
NCBI Official Synonym Symbols:CI15K; CI-15k��
NCBI Protein Information:NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
UniProt Protein Name:NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
UniProt Synonym Protein Names:Complex I-15 kDa; CI-15 kDa; NADH-ubiquinone oxidoreductase 15 kDa subunit
Protein Family:NADH dehydrogenase [ubiquinone] iron-sulfur protein
UniProt Gene Name:NDUFS5��
UniProt Entry Name:NDUS5_HUMAN
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