Human NCR3 Recombinant Protein (RPPB4069)
- SKU:
- RPPB4069
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14931
Description
| Product Name: | Human NCR3 Recombinant Protein |
| Product Code: | RPPB4069 |
| Size: | 20µg |
| Species: | Human |
| Target: | NCR3 |
| Synonyms: | Natural Cytotoxicity Triggering Receptor 3, LY117, 1C7, LymphocyteAntigen 117, Activating Natural Killer Receptor P30, Natural Killer CellP30-Related Protein, NK-p30, NKp30, CD337, MALS, Activating NK-A1 Receptor, CD337Antigen, NKP30. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | NCR3 protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLWVSQPPEI RTLEGSSAFL PCSFNASQGR LAIGSVTWFR DEVVPGKEVR NGTPEFRGRLAPLASSRFLH DHQAELHIRD VRGHDASIYV CRVEVLGLGV GTGNGTRLVV EKEHPQLGAG T |
CytotoxicityTriggering Receptor 3 also known as NCR3 is a natural cytotoxicity receptor(NCR) which assists NK cells in the lysis of tumor cells. Moreover, NCR3interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotidepolymorphism in the 5' untranslated region of NCR3 has been related with mildmalaria suceptibility. Three transcript variants encoding various isoforms havebeen found for this gene.
NCR3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 141 amino acids (19-138 a.a) andhaving a molecular mass of 15.3kDa.NCR3 is fused to a 21 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NCR3: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Apoptosis; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: integral to plasma membrane Biological Process: cell recognition; immune response; inflammatory response; positive regulation of natural killer cell mediated cytotoxicity Disease: Malaria, Mild, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] |
| UniProt Code: | O14931 |
| NCBI GenInfo Identifier: | 47605770 |
| NCBI Gene ID: | 259197 |
| NCBI Accession: | O14931.1 |
| UniProt Secondary Accession: | O14931,O14930, O14932, O95667, O95668, O95669, Q5ST89 Q5ST90, Q5ST91, B0S8F2, B0S8F4, B0S8F5, |
| UniProt Related Accession: | O14931 |
| Molecular Weight: | 201 |
| NCBI Full Name: | Natural cytotoxicity triggering receptor 3 |
| NCBI Synonym Full Names: | natural cytotoxicity triggering receptor 3 |
| NCBI Official Symbol: | NCR3�� |
| NCBI Official Synonym Symbols: | 1C7; MALS; CD337; LY117; NKp30�� |
| NCBI Protein Information: | natural cytotoxicity triggering receptor 3; NK-p30; lymphocyte antigen 117; activating NK-A1 receptor; activating natural killer receptor p30; natural killer cell p30-related protein |
| UniProt Protein Name: | Natural cytotoxicity triggering receptor 3 |
| UniProt Synonym Protein Names: | Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD_antigen: CD337 |
| Protein Family: | Natural cytotoxicity triggering receptor |
| UniProt Gene Name: | NCR3�� |
| UniProt Entry Name: | NCTR3_HUMAN |
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