Enzymes Recombinant Proteins

Human NAT6 Recombinant Protein (RPPB2002)

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SKU:
RPPB2002
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q93015
Research Area:
Enzymes

Description

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Product Name:Human NAT6 Recombinant Protein
Product Code:RPPB2002
Size:5µg
Species:Human
Target:NAT6
Synonyms:Protein fusion-2, FUS2, FUS-2, NAT6, N-acetyltransferase 6, Protein fus-2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The NAT6 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl and 20% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MQELTLSPGP AKLTPTLDPT HRMELILSTS PAELTLDPAC QPKLPLDSTC QPEMTFNPGP TELTLDPEHQ PEETPAPSLA ELTLEPVHRR PELLDACADL INDQWPRSRT SRLHSLGQSS DAFPLCLMLL SPHPTLEAAP VVVGHARLSR VLNQPQSLLV ETVVVARALR GRGFGRRLME GLEVFARARG FRKLHLTTHD QVHFYTHLGY QLGEPVQGLV FTSRRLPATL LNAFPTAPSP RPPRKAPNLT AQAAPRGPKG PPLPPPPPLP ECLTISPPVP SGPPSKSLLE TQYQNVRGRP IFWMEKDI

NAT6 is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to acrylamines. NAT6 is located mainly in the cytoplasm and its activity has been recognized by its feasibility to acetylate the N-terminus of proteins using a ping-pong-like mechanism and by its substrate specificity. Given that the NAT6 gene maps to the chromosomal region 3p21.3, which includes at least one tumor suppressor gene, the function of NAT6 plays an important role in cancer.

Recombinant Human NAT6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 328 amino acids (1-308 a.a.) and having a molecular mass of 35.9 kDa. NAT6 is fused to a 20 amino acid His Tag at N-terminus and purified by conventional chromatography techniques.

UniProt Protein Function:NAT6: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor. Belongs to the acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - phenylalanine; Tumor suppressor; Amino Acid Metabolism - tyrosine; Acetyltransferase; EC 2.3.1.-; Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 3p21.3

NCBI Summary:This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]
UniProt Code:Q93015
NCBI GenInfo Identifier:25008833
NCBI Gene ID:24142
NCBI Accession:Q93015.2
UniProt Secondary Accession:Q93015,Q93014,
UniProt Related Accession:Q93015
Molecular Weight:33,831 Da
NCBI Full Name:N-acetyltransferase 6
NCBI Synonym Full Names:N-acetyltransferase 6
NCBI Official Symbol:NAT6��
NCBI Official Synonym Symbols:FUS2; FUS-2��
NCBI Protein Information:N-acetyltransferase 6
UniProt Protein Name:N-acetyltransferase 6
UniProt Synonym Protein Names:Protein fusion-2; Protein fus-2
Protein Family:N-acetyltransferase
UniProt Gene Name:NAT6��
UniProt Entry Name:NAT6_HUMAN
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