Enzymes Recombinant Proteins

Human NARS Recombinant Protein (RPPB2000)

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SKU:
RPPB2000
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43776
Research Area:
Enzymes

Description

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Product Name:Human NARS Recombinant Protein
Product Code:RPPB2000
Size:10µg
Species:Human
Target:NARS
Synonyms:NARS, Asparaginyl-TRNASynthetase, AsnRS,EC 6.1.1.22, Asparaginyl-TRNA Synthetase, Cytoplasmic, Asparagine TRNALigase 1, Cytoplasmic, Asparagine--TRNA Ligase, Cytoplasmic, AsparagineTRNA Ligase 1, Cytoplasmic, NARS1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NARSprotein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH7.4) and 10%glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:GSSHHHHHH SSGLVPRGSH MGSMVLAELY VSDREGSDAT GDGTKEKPFK TGLKALMTVG KEPFPTIYVDSQKENERWNV ISKSQLKNIK KMWHREQMKS ESREKKEAED SLRREKNLEE AKKITIKNDP SLPEPKCVKIGALEGYRGQR VKVFGWVHRL RRQGKNLMFL VLRDGTGYLQ CVLADELCQC YNGVLLSTES SVAVYGMLNL TPKGKQAPGG HELSCDFWELIGLAPAGGAD NLINEESDVD VQLNNRHMMI RGENMSKILK ARSMVTRCFR DHFFDRGYYE VTPPTLVQTQVEGGATLFKL DYFGEEAFLT QSSQLYLETC LPALGDVFCI AQSYRAEQSR TRRHLAEYTH VEAECPFLTF DDLLNRLEDL VCDVVDRILK SPAGSIVHEL NPNFQPPKRPFKRMNYSDAI VWLKEHDVKK EDGTFYEFGE DIPEAPERLM TDTINEPILL CRFPVEIKSF YMQRCPEDSRLTESVDVLMP NVGEIVGGSM RIFDSEEILA GYKREGIDPT PYYWYTDQRK YGTCPHGGYG LGLERFLTWILNRYHIRDVC LYPRFVQRCT P

Aminoacyl-tRNA synthetases are a class of enzymes which charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase (NARS) is localized to the cytoplasm and is a member of the class II family of tRNA synthetases. The N-terminal domain characterizes the signature sequence for the eukaryotic asparaginyl-tRNA synthetases.

NARS Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 571 amino acids (1-548 a.a) andhaving a molecular mass of 65.3kDa. NARS is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:NARS: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Translation; EC 6.1.1.22; Ligase

Chromosomal Location of Human Ortholog: 18q21.31

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function:nucleic acid binding; asparagine-tRNA ligase activity; ATP binding

Biological Process: asparaginyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; gene expression

NCBI Summary:Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
UniProt Code:O43776
NCBI GenInfo Identifier:3915059
NCBI Gene ID:4677
NCBI Accession:O43776.1
UniProt Secondary Accession:O43776,Q53GU6, B4DG16,
UniProt Related Accession:O43776
Molecular Weight:548
NCBI Full Name:Asparagine--tRNA ligase, cytoplasmic
NCBI Synonym Full Names:asparaginyl-tRNA synthetase
NCBI Official Symbol:NARS��
NCBI Official Synonym Symbols:ASNRS; NARS1��
NCBI Protein Information:asparagine--tRNA ligase, cytoplasmic; asparagine tRNA ligase 1, cytoplasmic; asparaginyl-tRNA synthetase, cytoplasmic
UniProt Protein Name:Asparagine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names:Asparaginyl-tRNA synthetase; AsnRS
Protein Family:Probable sensor histidine kinase
UniProt Gene Name:NARS��
UniProt Entry Name:SYNC_HUMAN
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