Human NAP1L4 Recombinant Protein (RPPB4057)

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RPPB4057

Description

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Product Name:Human NAP1L4 Recombinant Protein
Product Code:RPPB4057
Size:20µg
Species:Human
Target:NAP1L4
Synonyms:Nucleosome assembly protein 1-like 4, Nucleosome assembly protein 2, NAP-2, NAP1L4, NAP2, hNAP2, NAP1L4b, NAP2L.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NAP1L4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMADHSFS DGVPSDSVEA AKNASNTEKL TDQVMQNPRV LAALQERLDN VPHTPSSYIE TLPKAVKRRI NALKQLQVRC AHIEAKFYEE VHDLERKYAA LYQPLFDKRR EFITGDVEPT DAESEWHSEN EEEEKLAGDM KSKVVVTEKA AATAEEPDPK GIPEFWFTIF RNVDMLSELV QEYDEPILKH LQDIKVKFSD PGQPMSFVLE FHFEPNDYFT NSVLTKTYKM KSEPDKADPF SFEGPEIVDC DGCTIDWKKG KNVTVKTIKK KQKHKGRGTV RTITKQVPNE SFFNFFNPLK ASGDGESLDE DSEFTLASDF EIGHFFRERI VPRAVLYFTG EAIEDDDNFE EGEEGEEEEL EGDEEGEDED DAEINPKV

Nucleosome Assembly Protein 1-Like 4 (NAP1L4) is a part of the nucleosome assembly protein (NAP) family which interacts with both core and linker histones. NAP1L4 plays a role as a histone chaperone due to his ability to shuttle between the cytoplasm and nucleus. NAP1L4 modulates transcriptional activation by target nuclear receptors. NAP1L4 is one of several located near the imprinted gene domain of 11p15.5 which is an important tumor-suppressor gene region.

NAP1L4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 398 amino acids (1-375) and having a molecular mass of 45.2 kDa.NAP1L4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NAP1L4: a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; unfolded protein binding

Biological Process: nucleosome assembly

NCBI Summary:This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
UniProt Code:Q99733
NCBI GenInfo Identifier:2498672
NCBI Gene ID:4676
NCBI Accession:Q99733.1
UniProt Related Accession:Q99733
Molecular Weight:
NCBI Full Name:Nucleosome assembly protein 1-like 4
NCBI Synonym Full Names:nucleosome assembly protein 1 like 4
NCBI Official Symbol:NAP1L4��
NCBI Official Synonym Symbols:NAP2; NAP2L; hNAP2; NAP1L4b��
NCBI Protein Information:nucleosome assembly protein 1-like 4
UniProt Protein Name:Nucleosome assembly protein 1-like 4
UniProt Synonym Protein Names:Nucleosome assembly protein 2; NAP-2
UniProt Gene Name:NAP1L4��
UniProt Entry Name:NP1L4_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q99733
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