Human NABP1 Recombinant Protein (RPPB4049)

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SKU:
RPPB4049
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96AH0

Description

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Product Name:Human NABP1 Recombinant Protein
Product Code:RPPB4049
Size:20µg
Species:Human
Target:NABP1
Synonyms:Nucleic Acid Binding Protein 1, OBFC2A, Sensor OfSingle-Strand DNA Complex Subunit B2, Single-Stranded DNA-Binding Protein 2, SSB2,Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A, NucleicAcid-Binding Protein 1, Oligonucleotide/Oligosaccharide-Binding Fold-ContainingProtein 2A, Sensor Of SsDNA Subunit B2, SOSS-B2, SOSS Complex Subunit B2, hSSB2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:NABP1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0) 0.2M, NaCl, 50% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKVADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNPDYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR

Nucleic acid binding protein 1 is a part of the SOSS complex, a multiprotein complexwhich functions downstream of the MRN complex to promote DNA repair and G2/Mcheckpoint. In the SOSS complex,NABP1 acts as a sensor of single-stranded DNA which binds to single-strandedDNA, in particularto polypyrimidines. The SOSS complex links with DNA lesions and affects diverse endpoints in the cellular DNA damage response including cell-cycle checkpointactivation, recombinational repair and maintenance of genomic stability. NABP1 is essential forefficient homologous recombination-dependent repair of double-strand breaks (DSBs) andATM-dependent signaling pathways.

NABP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (1-204 a.a) and having a molecular mass of 24.8kDa.NABP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; DNA repair, damage; Cell cycle regulationChromosomal Location of Human Ortholog: 2q32.3Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleusMolecular Function: protein binding; RNA binding; single-stranded DNA bindingBiological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation
UniProt Protein Details:
NCBI Summary:Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
UniProt Code:Q96AH0
NCBI GenInfo Identifier:72534722
NCBI Gene ID:64859
NCBI Accession:NP_001026886.1
UniProt Secondary Accession:Q96AH0,Q658Y8, Q9H5X6
UniProt Related Accession:Q96AH0
Molecular Weight:14,677 Da
NCBI Full Name:SOSS complex subunit B2 isoform 1
NCBI Synonym Full Names:nucleic acid binding protein 1
NCBI Official Symbol:NABP1��
NCBI Official Synonym Symbols:SSB2; OBFC2A; SOSS-B2��
NCBI Protein Information:SOSS complex subunit B2
UniProt Protein Name:SOSS complex subunit B2
UniProt Synonym Protein Names:Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2
Protein Family:SOSS complex
UniProt Gene Name:NABP1��
UniProt Entry Name:SOSB2_HUMAN
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