Human MZB1 Recombinant Protein (RPPB4048)

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SKU:
RPPB4048
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WU39

Description

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Product Name:Human MZB1 Recombinant Protein
Product Code:RPPB4048
Size:20µg
Species:Human
Target:MZB1
Synonyms:Marginal Zone B and B1 Cell-Specific Protein, MZB1, PACAP, Mesenteric Oestrogen-Dependent Adipose Gene- 7, Plasma Cell-Induced ER Protein 1, Proapoptotic Caspase Adaptor Protein, Mesenteric Estrogen-Dependent Adipose 7, Plasma Cell-Induced Resident Endoplasmic Reticulum Protein, Plasma Cell-Induced Resident ER Protein, Proapoptotic Caspase Adapter Protein, MEDA-7, pERp1, HSPC190, Caspase-2 Binding Protein, Marginal Zone B- And B1-Cell-Specific Protein, MEDA7, MGC29506.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MZB1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPAELWL TSYGVREVDQ VKRLTGPGLS EGPEPSISVM VTGGPWPTRL SRTCLHYLGE FGEDQIYEAH QQGRGALEAL LCGGPQGACS EKVSATREEL

Marginal zone B- and B1-cell-specific protein (MZB1) functions as a hormone-regulated adipokine/proinflammatory cytokine which is implicated in causing chronic inflammation and affecting cellular expansion. MZB1 links with immunoglobulin M (IgM) heavy and light chains and stimulate s IgM assembly and secretion. MZB1 exerts its effect by acting as a molecular chaperone or as an oxidoreductase as it exhibits a low level of oxidoreductase activity. MZB1 helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.

MZB1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (1-97) and having a molecular mass of 12.9 kDa.MZB1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MEDA-7: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Belongs to the PERP1 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: endoplasmic reticulum lumen; cytoplasm; extracellular region

Molecular Function:protein binding

Biological Process: integrin activation; apoptosis; positive regulation of cell proliferation; regulation of B cell proliferation; positive regulation of immunoglobulin biosynthetic process; regulation of cell proliferation

UniProt Code:Q8WU39
NCBI GenInfo Identifier:117938314
NCBI Gene ID:51237
NCBI Accession:NP_057543.2
UniProt Secondary Accession:Q8WU39,Q7Z6N2, Q96RL5, Q9P0T3, D2IYS0,
UniProt Related Accession:Q8WU39
Molecular Weight:6,681 Da
NCBI Full Name:marginal zone B- and B1-cell-specific protein
NCBI Synonym Full Names:marginal zone B and B1 cell-specific protein
NCBI Official Symbol:MZB1��
NCBI Official Synonym Symbols:PACAP; pERp1; MEDA-7��
NCBI Protein Information:marginal zone B- and B1-cell-specific protein; HSPC190; caspase-2 binding protein; mesenteric estrogen-dependent adipose 7; mesenteric oestrogen-dependent adipose gene- 7; plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein
UniProt Protein Name:Marginal zone B- and B1-cell-specific protein
UniProt Synonym Protein Names:Mesenteric estrogen-dependent adipose 7; MEDA-7; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein
Protein Family:Marginal zone B- and B1-cell-specific protein
UniProt Gene Name:MZB1��
UniProt Entry Name:MZB1_HUMAN
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