Human MZB1 Recombinant Protein (RPPB4048)
- SKU:
- RPPB4048
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WU39
Description
| Product Name: | Human MZB1 Recombinant Protein |
| Product Code: | RPPB4048 |
| Size: | 20µg |
| Species: | Human |
| Target: | MZB1 |
| Synonyms: | Marginal Zone B and B1 Cell-Specific Protein, MZB1, PACAP, Mesenteric Oestrogen-Dependent Adipose Gene- 7, Plasma Cell-Induced ER Protein 1, Proapoptotic Caspase Adaptor Protein, Mesenteric Estrogen-Dependent Adipose 7, Plasma Cell-Induced Resident Endoplasmic Reticulum Protein, Plasma Cell-Induced Resident ER Protein, Proapoptotic Caspase Adapter Protein, MEDA-7, pERp1, HSPC190, Caspase-2 Binding Protein, Marginal Zone B- And B1-Cell-Specific Protein, MEDA7, MGC29506. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MZB1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPAELWL TSYGVREVDQ VKRLTGPGLS EGPEPSISVM VTGGPWPTRL SRTCLHYLGE FGEDQIYEAH QQGRGALEAL LCGGPQGACS EKVSATREEL |
Marginal zone B- and B1-cell-specific protein (MZB1) functions as a hormone-regulated adipokine/proinflammatory cytokine which is implicated in causing chronic inflammation and affecting cellular expansion. MZB1 links with immunoglobulin M (IgM) heavy and light chains and stimulate s IgM assembly and secretion. MZB1 exerts its effect by acting as a molecular chaperone or as an oxidoreductase as it exhibits a low level of oxidoreductase activity. MZB1 helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.
MZB1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (1-97) and having a molecular mass of 12.9 kDa.MZB1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MEDA-7: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Belongs to the PERP1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: endoplasmic reticulum lumen; cytoplasm; extracellular region Molecular Function:protein binding Biological Process: integrin activation; apoptosis; positive regulation of cell proliferation; regulation of B cell proliferation; positive regulation of immunoglobulin biosynthetic process; regulation of cell proliferation |
| UniProt Code: | Q8WU39 |
| NCBI GenInfo Identifier: | 117938314 |
| NCBI Gene ID: | 51237 |
| NCBI Accession: | NP_057543.2 |
| UniProt Secondary Accession: | Q8WU39,Q7Z6N2, Q96RL5, Q9P0T3, D2IYS0, |
| UniProt Related Accession: | Q8WU39 |
| Molecular Weight: | 6,681 Da |
| NCBI Full Name: | marginal zone B- and B1-cell-specific protein |
| NCBI Synonym Full Names: | marginal zone B and B1 cell-specific protein |
| NCBI Official Symbol: | MZB1�� |
| NCBI Official Synonym Symbols: | PACAP; pERp1; MEDA-7�� |
| NCBI Protein Information: | marginal zone B- and B1-cell-specific protein; HSPC190; caspase-2 binding protein; mesenteric estrogen-dependent adipose 7; mesenteric oestrogen-dependent adipose gene- 7; plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein |
| UniProt Protein Name: | Marginal zone B- and B1-cell-specific protein |
| UniProt Synonym Protein Names: | Mesenteric estrogen-dependent adipose 7; MEDA-7; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein |
| Protein Family: | Marginal zone B- and B1-cell-specific protein |
| UniProt Gene Name: | MZB1�� |
| UniProt Entry Name: | MZB1_HUMAN |
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