Human MYOZ1 Recombinant Protein (RPPB5906)

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SKU:
RPPB5906
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NP98

Description

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Product Name:Human MYOZ1 Recombinant Protein
Product Code:RPPB5906
Size:20µg
Species:Human
Target:MYOZ1
Synonyms:CS-2, FATZ, MYOZ, Calsarcin-2, Filamin-, actinin- and telethonin-binding protein,Protein FATZ, MYOZ1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MYOZ1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPLSGTP APNKKRKSSK LIMELTGGGQ ESSGLNLGKK ISVPRDVMLE ELSLLTNRGS KMFKLRQMRV EKFIYENHPD VFSDSSMDHF QKFLPTVGGQ LGTAGQGFSY SKSNGRGGSQ AGGSGSAGQY GSDQQHHLGS GSGAGGTGGP AGQAGRGGAA GTAGVGETGS GDQAGGEGKH ITVFKTYISP WERAMGVDPQ QKMELGIDLL AYGAKAELPK YKSFNRTAMP YGGYEKASKR MTFQMPKFDL GPLLSEPLVL YNQNLSNRPS FNRTPIPWLS SGEPVDYNVD IGIPLDGETE EL

Myozenin 1 (MYOZ1) is a member of the myozenin family. MYOZ1 is mostly expressed in the skeletal muscle. Members of the myozenin family act as calcineurin-interacting proteins which helps tether calcineurin to the sarcomere of cardiac and skeletal muscle. The myozenin family plays a significant role in modulation of calcineurin signaling.

MYOZ1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 322 amino acids (1-299 a.a.) and having a molecular mass of 34.1kDa.MYOZ1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MYOZ1: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Belongs to the myozenin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: pseudopodium; nucleus; actin cytoskeleton

Molecular Function:protein binding; FATZ binding

Biological Process: myofibril assembly

NCBI Summary:The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
UniProt Code:Q9NP98
NCBI GenInfo Identifier:74734300
NCBI Gene ID:58529
NCBI Accession:Q9NP98.1
UniProt Secondary Accession:Q9NP98,Q9H1I7,
UniProt Related Accession:Q9NP98
Molecular Weight:299
NCBI Full Name:Myozenin-1
NCBI Synonym Full Names:myozenin 1
NCBI Official Symbol:MYOZ1��
NCBI Official Synonym Symbols:CS-2; FATZ; MYOZ��
NCBI Protein Information:myozenin-1; MYOZ1; calsarcin-2; filamin-, actinin- and telethonin-binding protein
UniProt Protein Name:Myozenin-1
UniProt Synonym Protein Names:Calsarcin-2; Filamin-, actinin- and telethonin-binding protein; Protein FATZ
Protein Family:Myozenin
UniProt Gene Name:MYOZ1��
UniProt Entry Name:MYOZ1_HUMAN
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