Human MYLPF Recombinant Protein (RPPB4042)
- SKU:
- RPPB4042
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96A32
Description
| Product Name: | Human MYLPF Recombinant Protein |
| Product Code: | RPPB4042 |
| Size: | 10µg |
| Species: | Human |
| Target: | MYLPF |
| Synonyms: | Myosin regulatory light chain 2 skeletal muscle isoform, Fast skeletal myosin light chain 2, MLC2B, MYLPF, MRLC2, MYL11, HUMMLC2B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MYLPF protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAPKRAKRRT VEGGSSSVFS MFDQTQIQEF KEAFTVIDQN RDGIIDKEDL RDTFAAMGRL NVKNEELDAM MKEASGPINF TVFLTMFGEK LKGADPEDVI TGAFKVLDPE GKGTIKKKFL EELLTTQCDR FSQEEIKNMW AAFPPDVGGN VDYKNICYVI THGDAKDQE |
Myosin regulatory light chains, including MRCL3, MYLPF and MYL9, regulate contraction in smooth muscle and non-muscle cells via phosphorylation by MLCK (myosin light chain kinase). Phosphorylation of myosin regulatory light chains, catalyzed by MLCK in the presence of calcium and calmodulin, increases the actin-activated myosin ATPase activity, thus regulating the contractile activity. MYLPF is vital for fast and slow skeletal muscle development.
MYLPF produced in E.Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids (1-169 a.a) and having a molecular mass of 21.2kDa.MYLPF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MYLPF: Myosin is an hexamer of 2 heavy chains and 4 light chains.Protein type: Motility/polarity/chemotaxis; MotorChromosomal Location of Human Ortholog: 16p11.2Cellular Component: cytosol; lysosomal membrane; muscle myosin complexMolecular Function: structural constituent of muscleBiological Process: muscle contraction; skeletal muscle development |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96A32 |
| NCBI GenInfo Identifier: | 1025812261 |
| NCBI Gene ID: | 29895 |
| NCBI Accession: | NP_001311387.1 |
| UniProt Secondary Accession: | Q96A32,Q14843, Q6IB41, B2RA83 |
| UniProt Related Accession: | Q96A32 |
| Molecular Weight: | 34.87kD |
| NCBI Full Name: | myosin regulatory light chain 2, skeletal muscle isoform |
| NCBI Synonym Full Names: | myosin light chain, phosphorylatable, fast skeletal muscle |
| NCBI Official Symbol: | MYLPF�� |
| NCBI Official Synonym Symbols: | MLC2B; MRLC2; MYL11; HUMMLC2B�� |
| NCBI Protein Information: | myosin regulatory light chain 2, skeletal muscle isoform |
| UniProt Protein Name: | Myosin regulatory light chain 2, skeletal muscle isoform |
| UniProt Synonym Protein Names: | Fast skeletal myosin light chain 2; MLC2B |
| Protein Family: | Myosin regulatory |
| UniProt Gene Name: | MYLPF�� |
| UniProt Entry Name: |
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