Human MYL6 Recombinant Protein (RPPB4037)

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SKU:
RPPB4037
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P60660

Description

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Product Name:Human MYL6 Recombinant Protein
Product Code:RPPB4037
Size:10µg
Species:Human
Target:MYL6
Synonyms:Myosin light polypeptide 6, 17 kDa myosin light chain, LC17, Myosin light chain 3, MLC-3, Myosin light chain alkali 3, Myosin light chain A3, Smooth muscle and nonmuscle myosin light chain alkali 6, MYL6, ESMLC, LC17A, LC17B, MLC1SM, MLC3NM, MLC3SM, LC17-GI, LC17-NM.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MYL6 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM TEEEVEMLVA GHEDSNGCIN YEELVRMVLN G

Myosin light polypeptide 6 (MYL6) is a hexameric ATPase cellular motor protein. MYL6 is composed of 2 heavy chains, 2 nonphosphorylatable alkali light chains, and 2o phosphorylatable regulatory light chains. MYL6 is a myosin alkali light chain which is expressed in smooth muscle and non-muscle tissues. MYL6 partakes in generating the force for cellular movements, thus having an imperative role in overall cellular function.

MYL6 Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�171 amino acids (1-151 a.a.) and having a molecular mass of 19.1kDa. The MYL6 is purified by proprietary chromatographic techniques.

UniProt Protein Function:MYL6: Regulatory light chain of myosin. Does not bind calcium. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: brush border; cytosol; extracellular matrix; membrane; myosin complex; unconventional myosin complex; vesicle

Molecular Function:actin-dependent ATPase activity; motor activity; protein binding; structural constituent of muscle

Biological Process: muscle contraction; muscle filament sliding; skeletal muscle development

NCBI Summary:Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P60660
NCBI GenInfo Identifier:47606436
NCBI Gene ID:4637
NCBI Accession:P60660.2
UniProt Secondary Accession:P60660,P16475, P24572, P24573, Q12790, Q561V9, Q6IAZ0 Q6IPY5,
UniProt Related Accession:P60660
Molecular Weight:17kDa
NCBI Full Name:Myosin light polypeptide 6
NCBI Synonym Full Names:myosin light chain 6
NCBI Official Symbol:MYL6��
NCBI Official Synonym Symbols:LC17; ESMLC; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM; LC17-GI; LC17-NM��
NCBI Protein Information:myosin light polypeptide 6
UniProt Protein Name:Myosin light polypeptide 6
UniProt Synonym Protein Names:17 kDa myosin light chain; LC17; Myosin light chain 3; MLC-3; Myosin light chain alkali 3; Myosin light chain A3; Smooth muscle and nonmuscle myosin light chain alkali 6
Protein Family:Myosin light polypeptide
UniProt Gene Name:MYL6��
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