Human MYL12A Recombinant Protein (RPPB4031)

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SKU:
RPPB4031
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P19105

Description

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Product Name:Human MYL12A Recombinant Protein
Product Code:RPPB4031
Size:20µg
Species:Human
Target:MYL12A
Synonyms:Myosin regulatory light chain 12A, MLC-2B, Myosin RLC, Myosin regulatory light chain 2 nonsarcomeric, Myosin regulatory light chain MRLC3, MYL12A, MLCB, MRLC3, RLC, MRCL3, MYL2B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MYL12A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSSKRT KTKTKKRPQR ATSNVFAMFD QSQIQEFKEA FNMIDQNRDG FIDKEDLHDM LASLGKNPTD EYLDAMMNEA PGPINFTMFL TMFGEKLNGT DPEDVIRNAF ACFDEEATGT IQEDYLRELL TTMGDRFTDE EVDELYREAP IDKKGNFNYI EFTRILKHGA KDKDD

Myosin regulatory light chain 12A (MYL12A) has a vital role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. The MYL12A protein is involved in cytokinesis, receptor capping, and cell locomotion.

MYL12A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (1-171 a.a.) and having a molecular mass of 22.4kDa.MYL12A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MRLC3: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains.
UniProt Protein Details:

Protein type:Contractile

Chromosomal Location of Human Ortholog: 18p11.31

Cellular Component: myosin II complex; stress fiber; cytosol; Z disc

Molecular Function:protein binding; glutamate receptor binding; calcium ion binding

Biological Process: axon guidance; regulation of cell shape; ephrin receptor signaling pathway

NCBI Summary:This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]
UniProt Code:P19105
NCBI GenInfo Identifier:127169
NCBI Gene ID:10627
NCBI Accession:P19105.2
UniProt Secondary Accession:P19105,Q53X45,
UniProt Related Accession:P19105
Molecular Weight:171
NCBI Full Name:Myosin regulatory light chain 12A
NCBI Synonym Full Names:myosin, light chain 12A, regulatory, non-sarcomeric
NCBI Official Symbol:MYL12A��
NCBI Official Synonym Symbols:MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24��
NCBI Protein Information:myosin regulatory light chain 12A; myosin RLC; myosin regulatory light chain 3; epididymis secretory protein Li 24; myosin regulatory light chain MRLC3; myosin regulatory light chain 2, nonsarcomeric; myosin, light polypeptide, regulatory, non-sarcomeric
UniProt Protein Name:Myosin regulatory light chain 12A
UniProt Synonym Protein Names:Epididymis secretory protein Li 24; HEL-S-24; MLC-2B; Myosin RLC; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRLC3
Protein Family:C-type mannose receptor
UniProt Gene Name:MYL12A��
UniProt Entry Name:ML12A_HUMAN
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