Human MXD3 Recombinant Protein (RPPB4019)

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SKU:
RPPB4019
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BW11

Description

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Product Name:Human MXD3 Recombinant Protein
Product Code:RPPB4019
Size:20µg
Species:Human
Target:MXD3
Synonyms:BHLHC13, MAD3, MYX, Max dimerization protein 3, Max dimerizer 3, Class C basic helix-loop-helix protein 13, bHLHc13, Max-associated protein 3, Max-interacting transcriptional repressor MAD3, MXD3 Human, MXD3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MXD3 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEPLASN IQVLLQAAEF LERREREAEH GYASLCPHRS PGPIHRRKKR PPQAPGAQDS GRSVHNELEK RRRAQLKRCL ERLKQQMPLG ADCARYTTLS LLRRARMHIQ KLEDQEQRAR QLKERLRSKQ QSLQRQLEQL RGLAGAAERE RLRADSLDSS GLSSERSDSD QEELEVDVES LVFGGEAELL RGFVAGQEHS YSHGGGAWL

MAX Dimerization Protein 3 (MXD3) belongs to the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. MXD3 forms a heterodimer with the cofactor MAX that connects specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disturbance of the MAX-MXD3 complex is correlated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of MXD3 encoding different isoforms have been described.

MXD3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 229 amino acids (1-206) and having a molecular mass of 25.9 kDa. MXD3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 5q35.3

Molecular Function:protein binding

NCBI Summary:This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
UniProt Code:Q9BW11
NCBI GenInfo Identifier:74733390
NCBI Gene ID:83463
NCBI Accession:Q9BW11.1
UniProt Secondary Accession:Q9BW11,Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3, B4E0J1,
UniProt Related Accession:Q9BW11
Molecular Weight:42,821 Da
NCBI Full Name:Max dimerization protein 3
NCBI Synonym Full Names:MAX dimerization protein 3
NCBI Official Symbol:MXD3��
NCBI Official Synonym Symbols:MYX; MAD3; BHLHC13��
NCBI Protein Information:max dimerization protein 3
UniProt Protein Name:Max dimerization protein 3
UniProt Synonym Protein Names:Class C basic helix-loop-helix protein 13; bHLHc13; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx
Protein Family:Max dimerization protein
UniProt Gene Name:MXD3��
UniProt Entry Name:MAD3_HUMAN
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