Human MX2 Recombinant Protein (RPPB4026)

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SKU:
RPPB4026
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P20592

Description

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Product Name:Human MX2 Recombinant Protein
Product Code:RPPB4026
Size:20µg
Species:Human
Target:MX2
Synonyms:Myxovirus (Influenza Virus) Resistance 2 (Homolog Of Mouse), Myxovirus Resistance Protein 2, P78-Related Protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The MX2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSIGIH LNAYFLETSK RLANQIPFII QYFMLRENGD SLQKAMMQIL QEKNRYSWLL QEQSETATKR RILKERIYRL TQARHALCQF SSKEIH

MX2 is a member of 2 protein families: the dynamin family and the large GTPases family. MX2 has a cytoplasmic and nuclear structure which is found in a granular pattern in the heterochromatin region under the nuclear envelope. The nuclear form has a NLS (nuclear localization signal) at the amino terminal end however it is missing in the cytoplasmic form as a result of the use of a different translation start codon. MX2 is upregulated by IFN-a, but unlike myxovirus resistance protein 1 has no antiviral activity.

MX2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 126 amino acids (626-715) and having a molecular mass of 14.9 kDa. MX2 is fused to a 36 amino acid His-tag at N-terminus.

UniProt Protein Function:MX2: has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]Protein type: G protein regulator, misc.Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytoplasm; nuclear pore; cytosol; nucleusMolecular Function: GTPase activity; GTP bindingBiological Process: protein transport; mRNA transport; metabolic process; regulation of cell cycle; regulation of nucleocytoplasmic transport; cytokine and chemokine mediated signaling pathway; response to virus; defense response; defense response to virus
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
UniProt Code:P20592
NCBI GenInfo Identifier:11342664
NCBI Gene ID:4600
NCBI Accession:NP_002454.1
UniProt Secondary Accession:P20592,B7Z5D3, D3DSI7
UniProt Related Accession:P20592
Molecular Weight:
NCBI Full Name:interferon-induced GTP-binding protein Mx2
NCBI Synonym Full Names:MX dynamin-like GTPase 2
NCBI Official Symbol:MX2��
NCBI Official Synonym Symbols:MXB��
NCBI Protein Information:interferon-induced GTP-binding protein Mx2; p78-related protein; myxovirus resistance protein 2; second interferon-induced protein p78; myxovirus (influenza virus) resistance 2; interferon-regulated resistance GTP-binding protein MXB
UniProt Protein Name:Interferon-induced GTP-binding protein Mx2
UniProt Synonym Protein Names:Interferon-regulated resistance GTP-binding protein MxB; Myxovirus resistance protein 2; p78-related protein
Protein Family:Interferon-induced GTP-binding protein
UniProt Gene Name:MX2��
UniProt Entry Name:MX2_HUMAN
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