Human MX1 Recombinant Protein (RPPB4024)

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RPPB4024

Description

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Product Name:Human MX1 Recombinant Protein
Product Code:RPPB4024
Size:20µg
Species:Human
Target:MX1
Synonyms:MX Dynamin-Like GTPase 1, Myxoma Resistance Protein 1, IFI-78K, IFI78, MX, Myxovirus (Influenza) Resistance 1,�
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MX1 protein solution (0.25mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMVVSEVD IAKADPAAAS HPLLLNGDAT VAQKNPGSVA ENNLCSQYEEKVRPCIDLID SLRALGVEQD LALPAIAVIG DQSSGKSSVL EALSGVALPR GSGIVTRCPL VLKLKKLVNEDKWRGKVSYQ DYEIEISDAS EVEKEINKAQ NAIAGEGMGISHELITLEIS SRDVPDLTLI DLPGITRVAV GNQPADIGYK IKTLIKKYIQRQETISLVVV PSNVDIATTE ALSMAQEVDP EGDRTIGILT KPDLVDKGTE DKVVDVVRNL VFHLKKGYMIVKCRGQQEIQ DQLSLSEALQ REKIFFENHP YFRDLLEEGK ATVPCLAEKL TSELITHICKSLPLLENQIK ETHQRITEEL QKYGVDIPED ENEKMFFLID KVNAFNQDITALMQGEETVG EEDIRLFTRL RHEFHKWSTI IENNFQEGHK ILSRKIQKFE NQYRGRELPG FVNYRTFETIVKQQIKALEE PAVDMLHTVT DMVRLAFTDV SIKNFEEFFN LHRTAKSKIE DIRAEQEREGEKLIRLHFQM EQIVYCQDQV YRGALQKVRE KELEEEKKKK SWDFGAFQSSSATDSSMEEI FQHLMAYHQE ASKRISSHIP LIIQFFMLQT YGQQLQKAML QLLQDKDTYS WLLKERSDTSDKRKFLKERL ARLTQARRRL AQFPG

Myxovirus Resistance 1, also known as MX1 is a guanosine triphosphate (GTP)-metabolizing protein which takes part in the cellular antiviral response. MX1 is induced by type I and type II IFN, and also antagonizes the replication process of some different RNA & DNA viruses. In addition, there is a related gene located adjacent to MX1 on chromosome 21, and there are multiple pseudogenes positioned in a cluster on chromosome 4.

MX1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 685 amino acids (1-662 a.a) andhaving a molecular mass of 77.9kDa.MX1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:MX1: Dynamin-like GTPase acting as a cell-autonomous host restriction factor against many viral pathogens. Shows activity against influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hantaan virus, Coxsackie virus CVB, Rift Valley fever virus RVFV, hepatitis B virus HBV, and Crimean- Congo hemorrhagic fever virus CCHFV. Belongs to the dynamin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; Apoptosis

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; cytosol

Molecular Function:GTPase activity; protein binding; GTP binding

Biological Process: negative regulation of viral genome replication; apoptosis; metabolic process; cytokine and chemokine mediated signaling pathway; response to virus; innate immune response; defense response; signal transduction; defense response to virus

NCBI Summary:This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:P20591
NCBI GenInfo Identifier:251757499
NCBI Gene ID:4599
NCBI Accession:P20591.4
UniProt Related Accession:P20591
Molecular Weight:
NCBI Full Name:Interferon-induced GTP-binding protein Mx1
NCBI Synonym Full Names:MX dynamin like GTPase 1
NCBI Official Symbol:MX1��
NCBI Official Synonym Symbols:MX; MxA; IFI78; IFI-78K��
NCBI Protein Information:interferon-induced GTP-binding protein Mx1
UniProt Protein Name:Interferon-induced GTP-binding protein Mx1
UniProt Synonym Protein Names:Interferon-induced protein p78; IFI-78K; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1Interferon-induced GTP-binding protein Mx1, N-terminally processed
Protein Family:Interferon-induced GTP-binding protein
UniProt Gene Name:MX1��
UniProt Entry Name:MX1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P20591
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