Enzymes Recombinant Proteins

Human MVD Recombinant Protein (RPPB1988)

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SKU:
RPPB1988
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P53602
Research Area:
Enzymes

Description

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Product Name:Human MVD Recombinant Protein
Product Code:RPPB1988
Size:10µg
Species:Human
Target:MVD
Synonyms:Diphosphomevalonate decarboxylase, Mevalonate (diphospho)decarboxylase, MDDase, Mevalonate pyrophosphate decarboxylase, MVD, MPD, FP17780.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MVD solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MASEKPLAAV TCTAPVNIAV IKYWGKRDEE LVLPINSSLS VTLHQDQLKT TTTAVISKDF TEDRIWLNGR EEDVGQPRLQ ACLREIRCLA RKRRNSRDGD PLPSSLSCKV HVASVNNFPT AAGLASSAAG YACLAYTLAR VYGVESDLSE VARRGSGSAC RSLYGGFVEW QMGEQADGKD SIARQVAPES HWPELRVLIL VVSAEKKLTG STVGMRASVE TSPLLRFRAE SVVPARMAEM ARCIRERDFP SFAQLTMKDS NQFHATCLDT FPPISYLNAI SWRIIHLVHR FNAHHGDTKV AYTFDAGPNA VIFTLDDTVA EFVAAVWHGF PPGSNGDTFL KGLQVRPAPL SAELQAALAM EPTPGGVKYI IVTQVGPGPQ ILDDPCAHLL GPDGLPKPAA

Diphosphomevalonate decarboxylase (MVD) catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. MVD decarboxylates and dehydrates its substrate while hydrolyzing ATP. MVD is expressed in the heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.

MVD Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 420 amino acids (1-400) and having a molecular mass of 45.6kDa.MVD is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MVD: Performs the first committed step in the biosynthesis of isoprenes. Belongs to the diphosphomevalonate decarboxylase family.
UniProt Protein Details:

Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lyase; EC 4.1.1.33

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: cytosol; peroxisome

Molecular Function:diphosphomevalonate decarboxylase activity; Hsp70 protein binding; protein homodimerization activity

Biological Process: cholesterol biosynthetic process; dolichyl diphosphate biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; positive regulation of cell proliferation

NCBI Summary:The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
UniProt Code:P53602
NCBI GenInfo Identifier:1706681
NCBI Gene ID:4597
NCBI Accession:P53602.1
UniProt Secondary Accession:P53602,Q53Y65,
UniProt Related Accession:P53602
Molecular Weight:43,405 Da
NCBI Full Name:Diphosphomevalonate decarboxylase
NCBI Synonym Full Names:mevalonate diphosphate decarboxylase
NCBI Official Symbol:MVD��
NCBI Official Synonym Symbols:MPD; MDDase; POROK7; FP17780��
NCBI Protein Information:diphosphomevalonate decarboxylase
UniProt Protein Name:Diphosphomevalonate decarboxylase
UniProt Synonym Protein Names:Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase
UniProt Gene Name:MVD��
UniProt Entry Name:MVD1_HUMAN
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