Human MTH1 / NUDT1 ELISA Kit

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SKU:
HUFI01913
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P36639
Sensitivity:
0.469ng/ml
Range:
0.781-50ng/ml
ELISA Type:
Sandwich
Synonyms:
NUDT1, MTH1, Nudix motif 1, Nudix motif 1, Nucleoside diphosphate-linked moiety X motif 1, 3.6.1.56, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1
Reactivity:
Human
Research Area:
Cell Biology

Description

Human MTH1 / NUDT1 ELISA

NUDT1 is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. NUDT1 is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphate thus reducing the risk of misincorporation. During replication and transcription, misincorporation of oxidized nucleoside triphosphates into DNA/RNA can lead to mutations that might cause cancer or neurodegeneration. Familial adenomatous polyposis and attenuated familial adenomatous polyposis are two types of NUDT1-related diseases. Purine metabolism and DNA damage are two other NUDT1-related processes. Hydrolase activity and snoRNA binding are two GO annotations linked to NUDT1. NUDT18 is a paralog of NUDT1.

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